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J Trace Elem Med Biol. 2015;31:188-92. doi: 10.1016/j.jtemb.2014.04.010. Epub 2014 May 14.

Chelation therapy in intoxications with mercury, lead and copper.

Author information

1
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
2
Faculty of Public Health, Hedmark University College, Elverum, Norway. Electronic address: marit.skaug@hihm.no.
3
Department of Science, Systems and Models, Roskilde University, Roskilde, Denmark.
4
Innlandet Hospital Trust, Kongsvinger Hospital Division, Kongsvinger, Norway.

Abstract

In the present review we provide an update of the appropriate use of chelating agents in the treatment of intoxications with compounds of mercury, lead and copper. The relatively new chelators meso-2,3-dimercaptosuccinic acid (DMSA) and 2,3-dimercapto-propanesulphonate (DMPS) can effectively mobilize deposits of mercury as well as of lead into the urine. These drugs can be administered orally and have relatively low toxicity compared to the classical antidote dimercaptopropanol (BAL). d-Penicillamine has been widely used in copper overload, although 2,3-dimercaptosuccinic acid or tetrathiomolybdate may be more suitable alternatives today. In copper-toxicity, a free radical scavenger might be recommended as adjuvant to the chelator therapy.

KEYWORDS:

DMPS; DMSA; Deferoxamine; Heavy metal; Penicillamine

PMID:
24894443
DOI:
10.1016/j.jtemb.2014.04.010
[Indexed for MEDLINE]

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