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Schizophr Res. 2014 Aug;157(1-3):1-7. doi: 10.1016/j.schres.2014.05.010. Epub 2014 Jun 2.

Suicide in first episode psychosis: a nationwide cohort study.

Author information

1
Department of Clinical Neuroscience, Insurance Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address: charlotte.bjorkenstam@ki.se.
2
Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
3
Centre for Health Equity Studies (CHESS), Stockholm University/Karolinska Institutet, Stockholm, Sweden; Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden.
4
Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden; Department of Neuroscience, Psychiatry, Uppsala University, Uppsala, Sweden.
5
Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden.

Abstract

BACKGROUND:

Relatively little is known about suicide in diagnostic subtypes of first episode psychosis (FEP). Our aim was to assess suicide rates and potential risk factors for suicide in FEP.

METHODS:

This is a national register-based cohort study of patients born in 1973-1978 in Sweden and who were hospitalized with a FEP between ages 15 and 30years (n=2819). The patients were followed from date of discharge until death, emigration, or 31st of December 2008. The suicide rates for six diagnostic subtypes of FEP were calculated. Suicide incidence rate ratios (IRRs) were calculated to evaluate the association between suicide and psychiatric, familial, social, and demographic factors.

RESULTS:

In total 121 patients died by suicide. The overall suicide rate was 4.3 (95% confidence interval [CI] 3.5-5.0) per 1000person-years. The highest suicide rates were found in depressive disorder with psychotic symptoms and in delusional disorder. In an adjusted model, the strongest risk factors for suicide were self-harm (IRR 2.7, CI 1.7-4.4) or a conviction for violent crime (IRR 2.0, CI 1.3-3.2). Also having a first-degree relative with a schizophrenia/bipolar diagnosis (IRR 2.1, CI 1.2-3.6) or substance use disorder (IRR 2.0, CI 1.2-3.2) were significant risk factors for suicide.

CONCLUSIONS:

Impulsive behavior such as self-harm as well as having a family history of severe mental disorder or substance use are important risk factors for suicide in FEP.

PMID:
24893904
DOI:
10.1016/j.schres.2014.05.010
[Indexed for MEDLINE]
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