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J Gen Virol. 2014 Sep;95(Pt 9):1861-9. doi: 10.1099/vir.0.066712-0. Epub 2014 Jun 3.

Epstein-Barr virus, the germinal centre and the development of Hodgkin's lymphoma.

Author information

1
Centre for Human Virology and the School of Cancer Sciences, University of Birmingham, Birmingham, UK.
2
Laboratory of Molecular Pathology, Department of Pathology and Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palack√Ĺ University, 77900 Olomouc, Czech Republic.
3
Department of Oral Biology and Biomedical Sciences & Oral Cancer Research and Coordinating Centre, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.
4
University of Groningen and University Medical Centre Groningen Department of Pathology and Medical Biology, Groningen, The Netherlands.
5
Centre for Human Virology and the School of Cancer Sciences, University of Birmingham, Birmingham, UK p.g.murray@bham.ac.uk.

Abstract

The relationship between Epstein-Barr virus (EBV) and the germinal centre (GC) of the asymptomatic host remains an enigma. The occasional appearance of EBV-positive germinal centres in some patients, particularly those with a history of immunosuppression, suggests that EBV numbers in the GC are subject to immune control. The relationship, if any, between lymphoid hyperplasia with EBV-positive germinal centres and subsequent or concurrent lymphomagenesis remains to be clarified. As far as the development of EBV-associated Hodgkin's lymphoma is concerned, the suppression of virus replication, mediated by LMP1 on the one hand, and the loss of B-cell receptor signalling on the other, appears to be an important pathogenic mechanism. A further important emerging concept is that alterations in the microenvironment of the EBV-infected B-cell may be important for lymphomagenesis.

PMID:
24893782
DOI:
10.1099/vir.0.066712-0
[Indexed for MEDLINE]

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