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J Diabetes. 2015 Mar;7(2):202-12. doi: 10.1111/1753-0407.12173. Epub 2014 Jul 29.

Meta-analysis of prospective studies on the effects of nut consumption on hypertension and type 2 diabetes mellitus.

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Department of Cardiology, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.



Inconclusive reports have been published on the consumption of nuts and the risk of hypertension and type 2 diabetes mellitus (T2DM). We performed a meta-analysis of prospective studies to assess the effects of nut consumption on hypertension and T2DM risks.


A PUBMED and EMBASE database search was performed. Summary relative risks (SRRs) and 95% confidence intervals (CIs) were calculated using a random-effects model. Q and I2 statistics were used to examine between-study heterogeneity.


A total of eight articles with nine prospective cohort studies (three hypertension studies and six T2DM studies) were selected. Using random effects models, we found that compared with never/rare consumers of nuts, those consuming >2 servings per week had an 8% lower risk of hypertension (SRR = 0.92, 95% CI: 0.87-0.97, P(heterogeneity)  = 0.590, I2  = 0%), while consumption of nuts at one serving per week had similar risk (SRR = 0.97, 95% CI: 0.83-1.13). In addition, nuts consumption was not associated with risk of T2DM (SRRs = 0.98, 95% CI: 0.84-1.15; P(heterogeneity)  = 0.008, I2  = 67.7%) on the basis of the highest versus lowest analysis. This null association was also shown in the dose-response analysis.


Findings from this meta-analysis indicate that consumption of nuts (>2 servings/week) may be inversely associated with hypertension risk, but not with T2DM risk.


hypertension; meta-analysis; nut consumption; type 2 diabetes mellitus; 关键词:高血压,meta分析,食用坚果,2型糖尿病

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