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J Neural Eng. 2014 Aug;11(4):046005. doi: 10.1088/1741-2560/11/4/046005. Epub 2014 Jun 3.

Closed-loop optical neural stimulation based on a 32-channel low-noise recording system with online spike sorting.

Author information

1
Imec, 3001 Leuven, Belgium. Department of Electrical Engineering, Katholieke Universiteit Leuven, 3001 Leuven, Belgium.

Abstract

OBJECTIVE:

Closed-loop operation of neuro-electronic systems is desirable for both scientific and clinical (neuroprosthesis) applications. Integrating optical stimulation with recording capability further enhances the selectivity of neural stimulation. We have developed a system enabling the local delivery of optical stimuli and the simultaneous electrical measuring of the neural activities in a closed-loop approach.

APPROACH:

The signal analysis is performed online through the implementation of a template matching algorithm. The system performance is demonstrated with the recorded data and in awake rats.

MAIN RESULTS:

Specifically, the neural activities are simultaneously recorded, detected, classified online (through spike sorting) from 32 channels, and used to trigger a light emitting diode light source using generated TTL signals.

SIGNIFICANCE:

A total processing time of 8 ms is achieved, suitable for optogenetic studies of brain mechanisms online.

PMID:
24891498
DOI:
10.1088/1741-2560/11/4/046005
[Indexed for MEDLINE]

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