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Endocrinol Metab Clin North Am. 2014 Jun;43(2):517-28. doi: 10.1016/j.ecl.2014.02.005.

Thyroid disease and the cardiovascular system.

Author information

1
Department of Biological Sciences and Geology, Queensborough Community College, 222-05 56th Avenue, Bayside, NY 11364, USA. Electronic address: saradanzi@gmail.com.
2
Department of Medicine and Cell Biology, NYU School of Medicine, New York, NY 10016, USA; Private Office, 935 Northern Boulevard, Great Neck, NY 11021, USA.

Abstract

Thyroid hormones, specifically triiodothyronine (T3), have significant effects on the heart and cardiovascular system. Hypothyroidism, hyperthyroidism, subclinical thyroid disease, and low T3 syndrome each cause cardiac and cardiovascular abnormalities through both genomic and nongenomic effects on cardiac myocytes and vascular smooth muscle cells. In compromised health, such as occurs in heart disease, alterations in thyroid hormone metabolism may further impair cardiac and cardiovascular function. Diagnosis and treatment of cardiac disease may benefit from including analysis of thyroid hormone status, including serum total T3 levels.

KEYWORDS:

Cardiac myocyte; Heart; Hyperthyroidism; Hypothyroidism; Subclinical; Thyroid hormone; Triiodothyronine

PMID:
24891175
DOI:
10.1016/j.ecl.2014.02.005
[Indexed for MEDLINE]

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