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Angew Chem Int Ed Engl. 2014 Aug 11;53(33):8722-6. doi: 10.1002/anie.201402542. Epub 2014 May 30.

Hydrogenation of esters to alcohols with a well-defined iron complex.

Author information

1
Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Strasse 29a, 18059 Rostock (Germany).

Abstract

We present the first base-free Fe-catalyzed ester reduction applying molecular hydrogen. Without any additives, a variety of carboxylic acid esters and lactones were hydrogenated with high efficiency. Computations reveal an outer-sphere mechanism involving simultaneous hydrogen transfer from the iron center and the ligand. This assumption is supported by NMR experiments.

KEYWORDS:

alcohols; esters; homogeneous catalysis; hydrogenation; iron

PMID:
24890043
DOI:
10.1002/anie.201402542
[Indexed for MEDLINE]
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