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J Pept Sci. 2014 Sep;20(9):675-9. doi: 10.1002/psc.2664. Epub 2014 Jun 2.

Matrix-assisted peptide synthesis on nanoparticles.

Author information

1
Department of Chemistry, Laboratory of Nano-Biomaterials, Bar Ilan University, Ramat Gan, 52900, Israel.

Abstract

We report a new method for multistep peptide synthesis on polymeric nanoparticles of differing sizes. Polymeric nanoparticles were functionalized via their temporary embedment into a magnetic inorganic matrix that allows multistep peptide synthesis. The matrix is removed at the end of the process for obtaining nanoparticles functionalized with peptides. The matrix-assisted synthesis on nanoparticles was proved by generating various biologically relevant peptides.

KEYWORDS:

embedded nanoparticle; magnetic matrix; nanoparticle; peptide; solid phase peptide synthesis

PMID:
24889925
DOI:
10.1002/psc.2664
[Indexed for MEDLINE]

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