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J Intern Med. 2015 Apr;277(4):456-67. doi: 10.1111/joim.12273. Epub 2014 Jun 20.

25-hydroxyvitamin D and increased all-cause mortality in very old women: the Newcastle 85+ study.

Author information

1
Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.

Abstract

OBJECTIVE:

To investigate the associations between low and high concentrations of baseline serum 25-hydroxyvitamin D [25(OH)D] and all-cause mortality in very old (≥85 years) men and women over 6 years.

DESIGN, SETTING AND SUBJECTS:

Prospective mortality data from 775 participants in the Newcastle 85+ Study were analysed for survival in relation to 25(OH)D (season-specific quartiles and predefined cut-off values) and sex using Cox proportional hazards models. The models were fitted to the entire and restricted (nonusers of vitamin D-containing supplements and medication) cohorts.

RESULTS:

For the entire cohort, mortality was higher in both the lowest and highest 25(OH)D season-specific quartiles [SQ1: hazard ratio (HR) 1.31, 95% confidence interval (CI) 1.01-1.69, P = 0.04; SQ4: HR 1.44, 95% CI 1.12-1.85, P = 0.004] compared with the combined middle quartiles (SQ2 + SQ3), after adjustment for sociodemographic factors. The increased risk for the highest quartile remained significant after further adjustment for lifestyle variables (SQ4: HR 1.37, 95% CI 1.06-1.77, P = 0.02) and was seen only in women in sex-specific analyses. Similarly, in sensitivity analyses with predefined 25(OH)D cut-off values, the highest 25(OH)D concentration (≥75 nmol L(-1) ) was associated with a 2.4-fold increased risk of mortality in women (restricted cohort) after adjusting for all covariates.

CONCLUSION:

Low and high season-specific 25(OH)D quartiles were associated with increased risks of mortality over 6 years in the very old; this effect was particularly noticeable in women, including those who reported taking vitamin D-containing supplements/medication.

KEYWORDS:

ageing; cohort study; mortality; risk factor; vitamins; women's health

PMID:
24889485
PMCID:
PMC4406141
DOI:
10.1111/joim.12273
[Indexed for MEDLINE]
Free PMC Article

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