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J Pediatr Surg. 2014 Jun;49(6):895-9. doi: 10.1016/j.jpedsurg.2014.01.049. Epub 2014 Feb 5.

Sensorineural hearing loss in congenital diaphragmatic hernia survivors is associated with postnatal management and not defect size.

Author information

1
Department of Surgery, Boston Children's Hospital, Boston, MA, USA.
2
Department of Otolaryngology and Communication Enhancement Boston Children's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
3
Department of Surgery, Boston Children's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
4
Department of Surgery, Boston Children's Hospital, Boston, MA, USA; Department of Anesthesia, Boston Children's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
5
Department of Surgery, Boston Children's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: catherine.chen@childrens.harvard.edu.

Abstract

BACKGROUND/PURPOSE:

We determined the incidence of sensorineural hearing loss (SNHL; >20dB at any frequency) in a contemporary cohort of congenital diaphragmatic hernia (CDH) survivors at a single tertiary care center and identified potential risk factors for SNHL.

METHODS:

From 2000 through 2011, clinical and audiologic data were collected on 122 surgically-repaired Bochdalek CDH patients. CDH defect size, duration of ventilation, and cumulative aminoglycoside treatment were used for multivariate logistic regression.

RESULTS:

Incidence of SNHL was 7.4% (9/122). We identified one significant independent predictor of SNHL: cumulative length of aminoglycoside treatment (P<.001; OR 1.44, 95% CI: 1.13-1.83).

CONCLUSIONS:

Over the last decade, the incidence of SNHL in our CDH patients is low compared to previous reports in the literature (7.4%) and is not associated with CDH defect size or the need for extracorporeal membrane oxygenation. Prolonged duration of aminoglycoside treatment increases the risk of SNHL independent of defect size and duration of ventilation.

KEYWORDS:

Congenital diaphragmatic hernia; Pediatric surgery; Sensorineural hearing loss

PMID:
24888830
DOI:
10.1016/j.jpedsurg.2014.01.049
[Indexed for MEDLINE]

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