Send to

Choose Destination
Saudi Med J. 2014 Jun;35(6):547-53.

Correlation between expression of miR-155 in colon cancer and serum carcinoembryonic antigen level and its contribution to recurrence and metastasis forecast.

Author information

Department of General Surgery, Affiliated Xiangyang Central Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.



To analyze the correlation between expression of miR-155 in colon cancer tissue and serum carcinoembryonic antigen (CEA) levels, and then explore its contribution to forecasting recurrence and metastasis.


Eighty-four pairs of colon cancer specimens and their corresponding non-tumor adjacent tissues were collected and analyzed between March 2009 and December 2011 in Xiangyang Central Hospital, Xiangyang, Hubei, China. The expression of miR-155 in both tissues was tested using reverse transcription-polymerase chain reaction (RT-PCR), the preoperative serum CEA level was assessed, and the postoperative serum CEA level was also assessed bimonthly during the follow-up period of 2 years.


The expression of miR-155 in colon cancer tissue was significantly higher than that in normal tissues (p<0.05), it had an obvious positive correlation with the preoperative serum CEA levels (p<0.01), and a negative correlation with time of duration since the serum CEA level increased again postoperatively (p<0.01). The expression of miR-155 in the recurrence and metastasis group was significantly higher (6.06+/-3.73 times) than that in the non-recurrence and non-metastasis group (p<0.05). An increase in the postoperative serum CEA levels was significantly correlated with recurrence and metastasis of the tumor postoperatively.


The expression of miR-155 is up-regulated in colon cancer tissue. A combination of miR-155 level assay in colon cancer tissue and the serum CEA level both pre- and postoperatively can afford more accurate information for diagnosis and prognosis, especially for predicting recurrence and metastasis postoperatively.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center