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Breast Cancer Res. 2014 May 26;16(3):R51. doi: 10.1186/bcr3662.

Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study.

Johnson N1,2, Dudbridge F3, Orr N4,5, Gibson L6, Jones ME7, Schoemaker MJ8, Folkerd EJ9, Haynes BP10, Hopper JL11, Southey MC12, Dite GS13, Apicella C14, Schmidt MK15, Broeks A16, Van't Veer LJ17, Atsma F18, Muir K19, Lophatananon A20, Fasching PA21,22, Beckmann MW23, Ekici AB24, Renner SP25, Sawyer E26, Tomlinson I27,28, Kerin M29, Miller N30, Burwinkel B31,32, Marme F33, Schneeweiss A34, Sohn C35,36, Guénel P37,38, Truong T39,40, Cordina E41,42, Menegaux F43,44, Bojesen SE45,46, Nordestgaard BG47,48, Flyger H49, Milne R50, Zamora MP51, Arias Perez JI52, Benitez J53,54, Bernstein L55, Anton-Culver H56, Ziogas A57, Clarke Dur C58, Brenner H59,60, Müller H61, Arndt V62, Dieffenbach AK63,64, Meindl A65, Heil J66, Bartram CR67, Schmutzler RK68, Brauch H69,70, Justenhoven C71,72, Ko YD73; GENICA (Gene Environment Interaction and Breast Cancer in Germany) Network, Nevanlinna H74, Muranen TA75, Aittomäki K76, Blomqvist C77, Matsuo K78, Dörk T79, Bogdanova NV80, Antonenkova NN81, Lindblom A82, Mannermaa A83,84,85, Kataja V86,87,88, Kosma VM89,90,91, Hartikainen JM92,93,94, Chenevix-Trench G95, Beesley J96; kConFab Investigators; Australian Ovarian Cancer Study Group, Wu AH97, Van den Berg D98, Tseng CC99, Lambrechts D100,101, Smeets D102,103, Neven P104, Wildiers H105, Chang-Claude J106, Rudolph A107, Nickels S108, Flesch-Janys D109,110, Radice P111, Peterlongo P112,113, Bonanni B114, Pensotti V115,116, Couch FJ117, Olson JE118, Wang X119, Fredericksen Z120, Pankratz VS121, Giles GG122,123, Severi G124,125, Baglietto L126,127, Haiman C128, Simard J129, Goldberg MS130, Labrèche F131, Dumont M132, Soucy P133, Teo S134,135, Yip CH136, Phuah SY137,138, Cornes BK139, Kristensen VN140,141, Grenaker Alnæs G142, Børresen-Dale AL143,144, Zheng W145, Winqvist R146, Pylkäs K147, Jukkola-Vuorinen A148, Grip M149, Andrulis IL150,151, Knight JA152,153, Glendon G154,155, Mulligan AM156,157, Devillee P158, Figueroa J159, Chanock SJ160, Lissowska J161, Sherman ME162, Hall P163, Schoof N164, Hooning M165, Hollestelle A166, Oldenburg RA167, Tilanus-Linthorst M168, Liu J169, Cox A170, Brock IW171, Reed MW172, Cross SS173, Blot W174,175, Signorello LB176,177,178, Pharoah PD179, Dunning AM180, Shah M181, Kang D182, Noh DY183, Park SK184,185,186, Choi JY187, Hartman M188,189,190, Miao H191,192, Lim WY193,194, Tang A195, Hamann U196, Försti A197,198, Rüdiger T199, Ulmer HU200, Jakubowska A201, Lubinski J202, Jaworska-Bieniek K203,204, Durda K205, Sangrajrang S206, Gaborieau V207, Brennan P208, McKay J209, Slager S210, Toland AE211, Vachon C212, Yannoukakos D213, Shen CY214,215, Yu JC216, Huang CS217, Hou MF218,219, González-Neira A220, Tessier DC221, Vincent D222, Bacot F223, Luccarini C224, Dennis J225, Michailidou K226, Bolla MK227, Wang J228, Easton DF229,230, García-Closas M231,232,233, Dowsett M234, Ashworth A235,236, Swerdlow AJ237,238,239, Peto J240, dos Santos Silva I241, Fletcher O242,243.

Author information

1
Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK. nichola.johnson@icr.ac.uk.
2
Division of Breast Cancer Research, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK. nichola.johnson@icr.ac.uk.
3
Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK. frank.dudbridge@lshtm.ac.uk.
4
Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK. Nicholas.Orr@icr.ac.uk.
5
Division of Breast Cancer Research, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK. Nicholas.Orr@icr.ac.uk.
6
Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK. lorna.gibson@lshtm.ac.uk.
7
Division of Genetics and Epidemiology, The Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey, SM2 5NG, UK. Michael.Jones@icr.ac.uk.
8
Division of Genetics and Epidemiology, The Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey, SM2 5NG, UK. Minouk.Schoemaker@icr.ac.uk.
9
The Academic Department of Biochemistry, The Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, UK. Elizabeth.Folkerd@icr.ac.uk.
10
The Academic Department of Biochemistry, The Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, UK. Ben.Haynes@icr.ac.uk.
11
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria, 3010, Australia. j.hopper@unimelb.edu.au.
12
Genetic Epidemiology Department, Department of Pathology, The University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria, 3010, Australia. msouthey@unimelb.edu.au.
13
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria, 3010, Australia. g.dite@unimelb.edu.au.
14
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria, 3010, Australia. capic@unimelb.edu.au.
15
Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands. mk.schmidt@nki.nl.
16
Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands. a.broeks@nki.nl.
17
Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands. l.vt.veer@nki.nl.
18
Sanquin, Radboud Universiteit Nijmegen, 6525 GA, Nijmegen, The Netherlands. f.atsma@iq.umc.nl.
19
Warwick Medical School, University of Warwick, Coventry, CV4 7AJ, UK. kenneth.muir@warwick.ac.uk.
20
Warwick Medical School, University of Warwick, Coventry, CV4 7AJ, UK. A.Lophatananon@warwick.ac.uk.
21
University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Postfach 2306, D-91012, Erlangen, Germany. peter.fasching@uk-erlangen.de.
22
David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, University of California, 10833 Le Conte Avenue, Los Angeles, CA, 90095, USA. peter.fasching@uk-erlangen.de.
23
University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Postfach 2306, D-91012, Erlangen, Germany. Fk-direktion@uk-erlangen.de.
24
Institute of Human Genetics, Friedrich Alexander University Erlangen- Nuremberg, Schlossplatz 4, 91054, Erlangen, Germany. Arif.Ekici@humgenet.uni-erlangen.de.
25
University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Postfach 2306, D-91012, Erlangen, Germany. stefan.renner@uk-erlangen.de.
26
Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy's & St. Thomas' NHS Foundation Trust in partnership with King's College London, Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK. elinor.sawyer@kcl.ac.uk.
27
Welcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK. iant@well.ox.ac.uk.
28
Oxford Biomedical Research Centre, University of Oxford, The Churchill Hospital, Old Road, Headington, OX3 7LE, Oxford, UK. iant@well.ox.ac.uk.
29
Surgery, Clinical Science Institute, Galway University Hospital and National University of Ireland, University Road, Galway, Ireland. michael.kerin@nuigalway.ie.
30
Surgery, Clinical Science Institute, Galway University Hospital and National University of Ireland, University Road, Galway, Ireland. nicola.miller@nuigalway.ie.
31
Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115, Heidelberg, Germany. Barbara.Burwinkel@med.uni-heidelberg.de.
32
Unit Molecular Epidemiology C080, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. Barbara.Burwinkel@med.uni-heidelberg.de.
33
Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115, Heidelberg, Germany. frederikmarme@gmail.com.
34
Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115, Heidelberg, Germany. Andreas.Schneeweiss@med.uni-heidelberg.de.
35
Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115, Heidelberg, Germany. Christof.Sohn@med.uni-heidelberg.de.
36
National Center for Tumor Diseases, University of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany. Christof.Sohn@med.uni-heidelberg.de.
37
Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654, Paris, France. pascal.guenel@inserm.fr.
38
University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654, Paris, France. pascal.guenel@inserm.fr.
39
Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654, Paris, France. therese.truong@inserm.fr.
40
University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654, Paris, France. therese.truong@inserm.fr.
41
Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654, Paris, France. emilie.cordina@inserm.fr.
42
University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654, Paris, France. emilie.cordina@inserm.fr.
43
Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 101 rue de Tolbiac, Villejuif, 75654, Paris, France. florence.menegaux@inserm.fr.
44
University Paris-Sud, UMRS 1018, 101 rue de Tolbiac, Villejuif, 75654, Paris, France. florence.menegaux@inserm.fr.
45
Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730, Herlev, Copenhagen, Denmark. stig.egil.bojesen@regionh.dk.
46
Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730, Herlev, Copenhagen, Denmark. stig.egil.bojesen@regionh.dk.
47
Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730, Herlev, Copenhagen, Denmark. brno@heh.regionh.dk.
48
Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, 2730, Herlev, Copenhagen, Denmark. brno@heh.regionh.dk.
49
Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev Rinvej 75, Herlev, 2730, Copenhagen, Denmark. Henrik.Flyger@regionh.dk.
50
Genetic and Molecular Epidemiology Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernandez Almagro, 3, 28029, Madrid, Spain. roger.milne@cancervic.org.au.
51
Servicio de Oncología Médica, Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046, Madrid, Spain. zamorapilar@gmail.com.
52
Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Avda. Dres. Fernández Vega, 107, Oviedo, Spain. jiarias@msn.com.
53
Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernandez Almagro, 3, 28029, Madrid, Spain. jbenitez@cnio.es.
54
Centro de Investigación en Red de Enfermedades Raras (CIBERER), Calle de Melchor Fernandez Almagro, 3, 28029, Madrid, Spain. jbenitez@cnio.es.
55
Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA. LBernstein@coh.org.
56
Department of Epidemiology, School of Medicine, University of California Irvine, 224 Irvine Hall, Irvine, California, 92697-7550, USA. hantoncu@uci.edu.
57
Department of Epidemiology, School of Medicine, University of California Irvine, 224 Irvine Hall, Irvine, California, 92697-7550, USA. aziogas@uci.edu.
58
Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, California, 95438, USA. tina@CPIC.org.
59
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121, Heidelberg, Germany. h.brenner@dkfz.de.
60
German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69121, Heidelberg, Germany. h.brenner@dkfz.de.
61
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121, Heidelberg, Germany. h.mueller@dkfz.de.
62
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121, Heidelberg, Germany. v.arndt@dkfz.de.
63
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69121, Heidelberg, Germany. A.Dieffenbach@dkfz-heidelberg.de.
64
German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69121, Heidelberg, Germany. A.Dieffenbach@dkfz-heidelberg.de.
65
Clinic of Gynecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Ismaninger Strasse 22, D-81675, Munich, Germany. alfons.meindl@lrz.tu-muenchen.de.
66
Department of Obstetrics and Gynecology, University of Heidelberg, Vosstrasse 9, 69115, Heidelberg, Germany. joerg.heil@med.uni-heidelberg.de.
67
Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69121, Heidelberg, Germany. cr_bartram@med.uni-heidelberg.de.
68
Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, Center of Molecular Medicine Cologne (CMMC), University Hospital of Cologne, ZMMK-Forschungsgebäude, Robert-Koch-Strasse 21, 50931, Cologne, Germany. rita.schmutzler@uk-koeln.de.
69
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Robert Bosch Stiftung GmbH, Heidehofstrasse 31, 70184, Stuttgart, Germany. hiltrud.brauch@ikp-stuttgart.de.
70
University of Tübingen, Geschwister-Scholl-Platz, 72074, Tübingen, Germany. hiltrud.brauch@ikp-stuttgart.de.
71
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Robert Bosch Stiftung GmbH, Heidehofstrasse 31, 70184, Stuttgart, Germany. christina.justenhoven@bioscientia.de.
72
University of Tübingen, Geschwister-Scholl-Platz, 72074, Tübingen, Germany. christina.justenhoven@bioscientia.de.
73
Department of Internal Medicine, Evangelische Kliniken Bonn GGmbH, Johanniter Krankenhaus, 53113, Bonn, Germany. Yon-Dschun.Ko@ek-bonn.de.
74
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Haartmaninkatu 2, P.O. Box 140, FIN-00029, Helsinki, Finland. Heli.Nevanlinna@hus.fi.
75
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Haartmaninkatu 2, P.O. Box 140, FIN-00029, Helsinki, Finland. taru.a.muranen@helsinki.fi.
76
Department of Clinical Genetics, Helsinki University Central Hospital, Haartmaninkatu 2, P.O. Box 140, FIN-00029, Helsinki, Finland. kristiina.aittomaki@hus.fi.
77
Department of Oncology, Helsinki University Central Hospital, Haartmaninkatu 2, P.O. Box 140, FIN-00029, Helsinki, Finland. carl.blomqvist@helsinki.fi.
78
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan. kmatsuo@aichi-cc.jp.
79
Department of Obstetrics and Gynaecology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. doerk.thilo@mh-hannover.de.
80
Department of Radiation Oncology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. nata_bogdanova@yahoo.com.
81
N.N. Alexandrov Research Institute of Oncology and Medical Radiology, 223040, p. Lesnoy, Minsk, Belarus. antonenkova.natalia.omd@tut.by.
82
Department of Molecular Medicine and Surgery, Karolinska Institutet, Solnavägen 1, 171 77, Solna, Stockholm, Sweden. Annika.Lindblom@ki.se.
83
School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Yliopistonranta 1, P.O. Box 1627, FI-70211, Kuopio, Finland. arto.mannermaa@uef.fi.
84
Biocenter Kuopio, Cancer Center of Eastern Finland, University of Eastern Finland, Yliopistonranta 1, P.O. Box 1627, FI-70211, Kuopio, Finland. arto.mannermaa@uef.fi.
85
Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, P.O. Box 100, FI-70029, Kuopio, Finland. arto.mannermaa@uef.fi.
86
School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Yliopistonranta 1, P.O. Box 1627, FI-70211, Kuopio, Finland. vesa.kataja@kuh.fi.
87
Biocenter Kuopio, Cancer Center of Eastern Finland, University of Eastern Finland, Yliopistonranta 1, P.O. Box 1627, FI-70211, Kuopio, Finland. vesa.kataja@kuh.fi.
88
Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, P.O. Box 100, FI-70029, Kuopio, Finland. vesa.kataja@kuh.fi.
89
School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Yliopistonranta 1, P.O. Box 1627, FI-70211, Kuopio, Finland. veli-matti.kosma@uef.fi.
90
Biocenter Kuopio, Cancer Center of Eastern Finland, University of Eastern Finland, Yliopistonranta 1, P.O. Box 1627, FI-70211, Kuopio, Finland. veli-matti.kosma@uef.fi.
91
Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, P.O. Box 100, FI-70029, Kuopio, Finland. veli-matti.kosma@uef.fi.
92
School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Yliopistonranta 1, P.O. Box 1627, FI-70211, Kuopio, Finland. jaana.hartikainen@uef.fi.
93
Biocenter Kuopio, Cancer Center of Eastern Finland, University of Eastern Finland, Yliopistonranta 1, P.O. Box 1627, FI-70211, Kuopio, Finland. jaana.hartikainen@uef.fi.
94
Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, P.O. Box 100, FI-70029, Kuopio, Finland. jaana.hartikainen@uef.fi.
95
Department of Genetics, Queensland Institute of Medical Research, 300 Herston Rd, Herston, Brisbane Queensland, 4006, Australia. Georgia.Trench@qimr.edu.au.
96
Department of Genetics, Queensland Institute of Medical Research, 300 Herston Rd, Herston, Brisbane Queensland, 4006, Australia. Jonathan.Beesley@qimr.edu.au.
97
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1975 Zonal Ave, Los Angeles, CA, 90033, USA. Anna.Wu@med.usc.edu.
98
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1975 Zonal Ave, Los Angeles, CA, 90033, USA. dvandenb@usc.edu.
99
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1975 Zonal Ave, Los Angeles, CA, 90033, USA. Chiu-chen.Tseng@med.usc.edu.
100
Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Oude Markt 13 - bus 5005, 3000, Leuven, Belgium. Diether.Lambrechts@vib-kuleuven.be.
101
Vesalius Research Center, VIB, Herestraat 49, box 912, Onderwijs & Navorsing 4, Building 404-24, 3000, Leuven, Belgium. Diether.Lambrechts@vib-kuleuven.be.
102
Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Oude Markt 13 - bus 5005, 3000, Leuven, Belgium. Dominiek.Smeets@vib-kuleuven.be.
103
Vesalius Research Center, VIB, Herestraat 49, box 912, Onderwijs & Navorsing 4, Building 404-24, 3000, Leuven, Belgium. Dominiek.Smeets@vib-kuleuven.be.
104
Multidisciplinary Breast Center, University Hospital Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium. Patrick.Neven@uzleuven.be.
105
Multidisciplinary Breast Center, University Hospital Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium. Hans.Wildiers@uzleuven.be.
106
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. j.chang-claude@dkfz-heidelberg.de.
107
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. a.rudolph@dkfz.de.
108
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. s.nickels@dkfz.de.
109
Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Martinistrasse 52, D - 20246, Hamburg, Germany. flesch@uke.uni-hamburg.de.
110
Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Martinistrasse 52, D - 20246, Hamburg, Germany. flesch@uke.uni-hamburg.de.
111
Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Via Venezian 1, 20133, Milan, Italy. paolo.radice@istitutotumori.mi.it.
112
Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Via Venezian 1, 20133, Milan, Italy. paolo.peterlongo@ifom.eu.
113
IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139, Milan, Italy. paolo.peterlongo@ifom.eu.
114
Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Via Giuseppe Ripamonti 435, 20141, Milan, Italy. bernardo.bonanni@ieo.it.
115
IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139, Milan, Italy. valeria.pensotti@ifom.eu.
116
Cogentech Cancer Genetic Test Laboratory, IFOM-IEO Campus, Via Adamello16, 20139, Milan, Italy. valeria.pensotti@ifom.eu.
117
Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. couch.fergus@mayo.edu.
118
Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. olsonj@mayo.edu.
119
Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. wang.xianshu@mayo.edu.
120
Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. Zach.Fredericksen@northerntool.com.
121
Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. pankratz.vernon@mayo.edu.
122
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria, 3010, Australia. Graham.Giles@cancervic.org.au.
123
Cancer Epidemiology Centre, The Cancer Council Victoria, 615 St Kilda Road, Melbourne, Victoria, 3004, Australia. Graham.Giles@cancervic.org.au.
124
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria, 3010, Australia. Gianluca.severi@cancervic.org.au.
125
Cancer Epidemiology Centre, The Cancer Council Victoria, 615 St Kilda Road, Melbourne, Victoria, 3004, Australia. Gianluca.severi@cancervic.org.au.
126
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, 1-100 Gratton Street, Parkville, Melbourne, Victoria, 3010, Australia. Laura.baglietto@cancervic.org.au.
127
Cancer Epidemiology Centre, The Cancer Council Victoria, 615 St Kilda Road, Melbourne, Victoria, 3004, Australia. Laura.baglietto@cancervic.org.au.
128
Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Oude Markt 13 - bus 5005, 3000, Leuven, Belgium. Christopher.Haiman@med.usc.edu.
129
Department of Medicine, McGill University and Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, 687 Pine Avenue West, Montréal, Québec, H3A 1A1, Canada. jacques.simard@crchul.ulaval.ca.
130
Department of Medicine, McGill University and Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, 687 Pine Avenue West, Montréal, Québec, H3A 1A1, Canada. mark.goldberg@mcgill.ca.
131
Department of Social and Preventive Medicine and Department of Environmental and Occupational Health at Work, University of Montréal, Marguerite d'Youville Pavilion, 2375 Côte Ste-Catherine, Suite 4095, Montréal, Québec, H3T 1A8, Canada. France.Labreche@irsst.qc.ca.
132
Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2325 Rue de l'Université, Québec City, Québec, G1V 0A6, Canada. martine.dumont@crchul.ulaval.ca.
133
Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2325 Rue de l'Université, Québec City, Québec, G1V 0A6, Canada. penny.soucy@crchul.ulaval.ca.
134
Breast Cancer Research Unit, University of Malaya Cancer Research Institute, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. soohwang.teo@carif.com.my.
135
Cancer Research Initiatives Foundation, Sime Darby Medical Centre Subang Jaya, 1, Jalan SS 12 / 1A, 47500, Subang Jaya, Selangor Darul Ehsan, Malaysia. soohwang.teo@carif.com.my.
136
Breast Cancer Research Unit, University of Malaya Cancer Research Institute, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. yipch@um.edu.my.
137
Breast Cancer Research Unit, University of Malaya Cancer Research Institute, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. szeyee.phuah@carif.com.my.
138
Cancer Research Initiatives Foundation, Sime Darby Medical Centre Subang Jaya, 1, Jalan SS 12 / 1A, 47500, Subang Jaya, Selangor Darul Ehsan, Malaysia. szeyee.phuah@carif.com.my.
139
Singapore Eye Research Institute, National University of Singapore, Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore, 168751, Singapore. belinda.cornes@gmail.com.
140
Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, N-0310, Oslo, Norway. Vessela.N.Kristensen@rr-research.no.
141
Faculty of Medicine (Faculty Division Ahus), University of Oslo, Sogn Arena, Klaus Torgårds vei 3, 2. etg, 0372, Oslo, Norway. Vessela.N.Kristensen@rr-research.no.
142
Faculty of Medicine (Faculty Division Ahus), University of Oslo, Sogn Arena, Klaus Torgårds vei 3, 2. etg, 0372, Oslo, Norway. Grethe.I.Grenaker.Alnas@rr-research.no.
143
Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, N-0310, Oslo, Norway. alb@radium.uio.no.
144
Faculty of Medicine (Faculty Division Ahus), University of Oslo, Sogn Arena, Klaus Torgårds vei 3, 2. etg, 0372, Oslo, Norway. alb@radium.uio.no.
145
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, 1161 21st Ave S # T1217, Nashville, TN, 37232, USA. wei.zheng@Vanderbilt.Edu.
146
Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu University Hospital, Kajaanintie 50, 90220, Oulu, Finland. robert.winqvist@oulu.fi.
147
Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu University Hospital, Kajaanintie 50, 90220, Oulu, Finland. katri.pylkas@oulu.fi.
148
Department of Oncology, Oulu University Hospital, University of Oulu, Kajaanintie 50, 90220, Oulu, Finland. arja.jukkola-vuorinen@ppshp.fi.
149
Department of Surgery, Oulu University Hospital, University of Oulu, Kajaanintie 50, 90220, Oulu, Finland. mervi.grip@ppshp.fi.
150
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 982 - 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada. andrulis@lunenfeld.ca.
151
Department of Molecular Genetics, University of Toronto, Medical Science Building, Room 4386, 1 King's College Cir, Toronto, Ontario, M5S 1A8, Canada. andrulis@lunenfeld.ca.
152
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 982 - 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada. knight@lunenfeld.ca.
153
Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, 6th floor, 155 College St, Toronto, Ontario, M5T 3M7, Canada. knight@lunenfeld.ca.
154
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 982 - 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada. gglendon@uhnresearch.ca.
155
Ontario Cancer Genetics Network, 620 University Avenue, Toronto, Ontario, M5G 2L7, Canada. gglendon@uhnresearch.ca.
156
Department of Laboratory Medicine and Pathobiology, University of Toronto, Medical Sciences Building, 6th Floor, 1 King's College Cir, Toronto, Ontario, M5S 1A8, Canada. AnnaMarie.Mulligan@uhn.ca.
157
University Health Network, R. Fraser Elliott Building, 1st Floor, 190 Elizabeth St, Toronto, Ontario, M5G 2C4, Canada. AnnaMarie.Mulligan@uhn.ca.
158
Department of Human Genetics & Department of Pathology, Leiden University Medical Center, Einthovenweg 20, 2333, ZC, Leiden, The Netherlands. p.devilee@lumc.nl.
159
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Rockville, MD, 20850, USA. figueroaj@mail.nih.gov.
160
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Rockville, MD, 20850, USA. chanocks@mail.nih.gov.
161
Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Roentena 5, 02-781, Warsaw, Poland. lissowsj@coi.waw.pl.
162
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Rockville, MD, 20850, USA. shermanm@mail.nih.gov.
163
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solnavägen 1, Stockholm, 17177, Sweden. Per.Hall@ki.se.
164
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solnavägen 1, Stockholm, 17177, Sweden. nils.schoof@ki.se.
165
Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Groene Hilledijk 301, Rotterdam, EA, 3075, The Netherlands. m.hooning@erasmusmc.nl.
166
Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Groene Hilledijk 301, 3075, EA, Rotterdam, The Netherlands. a.hollestelle@erasmusmc.nl.
167
Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Groene Hilledijk 301, 3075, EA, Rotterdam, The Netherlands. r.oldenburg@erasmusmc.nl.
168
Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Groene Hilledijk 301, 3075, EA, Rotterdam, The Netherlands. m.tilanus-linthorst@erasmusmc.nl.
169
Human Genetics Division, Genome Institute of Singapore, 60 Biopolis St, Singapore, 138672, Singapore. liuj3@gis.a-star.edu.sg.
170
Institute for Cancer Studies, Department of Oncology, CRUK/YCR Sheffield Cancer Research Centre, University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK. a.cox@sheffield.ac.uk.
171
Institute for Cancer Studies, Department of Oncology, CRUK/YCR Sheffield Cancer Research Centre, University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK. i.w.brock@shef.ac.uk.
172
Academic Unit of Surgical Oncology, Department of Oncology, CRUK/YCR Sheffield Cancer Research Centre, University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK. m.w.reed@sheffield.ac.uk.
173
Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK. s.s.cross@sheffield.ac.uk.
174
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, 1161 21st Ave S # T1217, Nashville, TN, 37232, USA. william.j.blot@Vanderbilt.Edu.
175
International Epidemiology Institute, 1455 Research Blvd, Rockville, MD, 20850, USA. william.j.blot@Vanderbilt.Edu.
176
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA. Signorello@hsph.harvard.edu.
177
Channing Division of Network Medicine, Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA. Signorello@hsph.harvard.edu.
178
Dana-Farber/Harvard Cancer Center, 450 Brookline Ave, Boston, MA, 02215, USA. Signorello@hsph.harvard.edu.
179
Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK. paul.pharoah@srl.cam.ac.uk.
180
Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK. amd24@medschl.cam.ac.uk.
181
Seoul National University College of Medicine, Yongeon-103 Daehangno, Jongno-gu, Seoul, 110-799, Korea. ms483@medschl.cam.ac.uk.
182
Seoul National University College of Medicine, Yongeon-103 Daehangno, Jongno-gu, Seoul, 110-799, Korea. dhkang@snu.ac.kr.
183
Seoul National University College of Medicine, Yongeon-103 Daehangno, Jongno-gu, Seoul, 110-799, Korea. dynoh@snu.ac.kr.
184
Department of Preventive Medicine, Seoul National University College of Medicine, Yongeon-103 Daehangno, Jongno-gu, Seoul, 110-799, Korea. suepark@snu.ac.kr.
185
Department of Biomedical Science, Seoul National University Graduate School, Yongeon-103 Daehangno, Jongno-gu, Seoul, 110-799, Korea. suepark@snu.ac.kr.
186
Cancer Research Institute, Seoul National University, Yongeon-103 Daehangno, Jongno-gu, Seoul, 110-799, Korea. suepark@snu.ac.kr.
187
Seoul National University College of Medicine, Yongeon-103 Daehangno, Jongno-gu, Seoul, 110-799, Korea. jiyeob.choi@gmail.com.
188
Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 1E, Kent Ridge Road, Singapore, 119228, Singapore. mikael_hartman@nuhs.edu.sg.
189
National University Health System, 1E, Kent Ridge Road, Singapore, 119228, Singapore. mikael_hartman@nuhs.edu.sg.
190
Saw Swee Hock School of Public Health, National University of Singapore, MD3, 16 Medical Drive, Singapore, 117597, Singapore. mikael_hartman@nuhs.edu.sg.
191
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA. ephmh@nus.edu.sg.
192
Channing Division of Network Medicine, Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA. ephmh@nus.edu.sg.
193
National University Health System, 1E, Kent Ridge Road, Singapore, 119228, Singapore. ephlwy@nus.edu.sg.
194
Saw Swee Hock School of Public Health, National University of Singapore, MD3, 16 Medical Drive, Singapore, 117597, Singapore. ephlwy@nus.edu.sg.
195
Division of General Surgery, National University Health System, 1E, Kent Ridge Road, Singapore, 119228, Singapore. Anthony_tang@nuhs.edu.sg.
196
Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. u.hamann@dkfz-heidelberg.de.
197
Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. A.Foersti@dkfz-heidelberg.de.
198
Center for Primary Health Care Research, University of Lund, Paradisgatan 5, SE-221 00, Lund, Malmö, Sweden. A.Foersti@dkfz-heidelberg.de.
199
Institute of Pathology, Städtisches Klinikum Karlsruhe, Moltkestrasse 90, 76133, Karlsruhe, Germany. Thomas.Ruediger@klinikum-karlsruhe.de.
200
Frauenklinik der Stadtklinik Baden-Baden, Balger Strasse 50, 76532, Baden-Württemberg, Germany. hu.ulmer@klinikum-mittelbaden.de.
201
Department of Genetics and Pathology, Pomeranian Medical University, Rybacka 1, 70-204, Szczecin, Poland. aniaj@sci.pam.szczecin.pl.
202
Department of Genetics and Pathology, Pomeranian Medical University, Rybacka 1, 70-204, Szczecin, Poland. lubinski@sci.pam.szczecin.pl.
203
Department of Genetics and Pathology, Pomeranian Medical University, Rybacka 1, 70-204, Szczecin, Poland. ka_jaworska@wp.pl.
204
Postgraduate School of Molecular Medicine, Warsaw Medical University, Żwirki i Wigury 61, 02-091, Warsaw, Poland. ka_jaworska@wp.pl.
205
Department of Genetics and Pathology, Pomeranian Medical University, Rybacka 1, 70-204, Szczecin, Poland. k.durda@onet.pl.
206
National Cancer Institute, 268/1 Rama VI Road, Rajathevi, Bangkok, 10400, Thailand. sulee@health.moph.go.th.
207
International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon, CEDEX 08, France. gaborieau@iarc.fr.
208
International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon, CEDEX 08, France. brennan@iarc.fr.
209
International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon, CEDEX 08, France. mckay@iarc.fr.
210
Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. slager.susan@mayo.edu.
211
Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, 410 W. 10th Avenue, Columbus, OH, 43210, USA. amanda.toland@osumc.edu.
212
Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. vachon.celine@mayo.edu.
213
Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research "Demokritos", Aghia Paraskevi Attikis 153 10, Athens, Greece. yannouka@rrp.demokritos.gr.
214
College of Public Health, China Medical University, No.91, Hsueh-Shih Road, Taichung, 40402, Taiwan. bmcys@ibms.sinica.edu.tw.
215
Institute of Biomedical Sciences, Academia Sinica, 2 Academia Road, Nankang, Taipei 115, Taiwan. bmcys@ibms.sinica.edu.tw.
216
Department of Surgery, Tri-Service General Hospital, No.325, Sec.2 Chenggong Road, Taipei City 114, Neihu District, Taiwan. doc20106@ndmctsgh.edu.tw.
217
Department of Surgery, National Taiwan University Hospital, No.1, Changde Street, Taipei City, 10048, Zhongzheng District, Taiwan. huangcs@ntu.edu.tw.
218
Cancer Center, Kaohsiung Medical University Chung-Ho Memorial Hospital, No.100, Tzyou 1st Road, Kaohsiung, 807, Taiwan. mifeho@kmu.edu.tw.
219
Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, No.100, Tzyou 1st Road, Kaohsiung, 807, Taiwan. mifeho@kmu.edu.tw.
220
Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernandez Almagro, 3, 28029, Madrid, Spain. agonzalez@cnio.es.
221
McGill University and Génome Québec Innovation Centre, 740, Dr. Penfield Avenue, Room 7104, Montréal, Québec, H3A 0G1, Canada. dtessier@genomequebec.com.
222
McGill University and Génome Québec Innovation Centre, 740, Dr. Penfield Avenue, Room 7104, Montréal, Québec, H3A 0G1, Canada. daniel.vincent@mail.mcgill.ca.
223
McGill University and Génome Québec Innovation Centre, 740, Dr. Penfield Avenue, Room 7104, Montréal, Québec, H3A 0G1, Canada. francois.bacot@mail.mcgill.ca.
224
Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK. cl533@medschl.cam.ac.uk.
225
Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK. jgd29@cam.ac.uk.
226
Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK. km533@medschl.cam.ac.uk.
227
Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK. mkh39@medschl.cam.ac.uk.
228
Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK. jccw2@medschl.cam.ac.uk.
229
Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK. dfe20@medschl.cam.ac.uk.
230
Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK. dfe20@medschl.cam.ac.uk.
231
Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK. Montse.GarciaClosas@icr.ac.uk.
232
Division of Breast Cancer Research, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK. Montse.GarciaClosas@icr.ac.uk.
233
Division of Genetics and Epidemiology, The Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey, SM2 5NG, UK. Montse.GarciaClosas@icr.ac.uk.
234
The Academic Department of Biochemistry, The Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, UK. Mitch.Dowsett@icr.ac.uk.
235
Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK. Alan.Ashworth@icr.ac.uk.
236
Division of Breast Cancer Research, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK. Alan.Ashworth@icr.ac.uk.
237
Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK. Anthony.Swerdlow@icr.ac.uk.
238
Division of Breast Cancer Research, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK. Anthony.Swerdlow@icr.ac.uk.
239
Division of Genetics and Epidemiology, The Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey, SM2 5NG, UK. Anthony.Swerdlow@icr.ac.uk.
240
Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK. Julian.Peto@lshtm.ac.uk.
241
Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK. Isabel.Silva@lshtm.ac.uk.
242
Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK. Olivia.Fletcher@icr.ac.uk.
243
Division of Breast Cancer Research, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK. Olivia.Fletcher@icr.ac.uk.

Abstract

INTRODUCTION:

We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years.

METHODS:

We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagnosis, ethnicity, age at menarche or tumor characteristics.

RESULTS:

We confirmed the association of rs10235235 with breast cancer risk for women of European ancestry but found no evidence that this association differed with age at diagnosis. Heterozygote and homozygote odds ratios (ORs) were OR = 0.98 (95% CI 0.94, 1.01; P = 0.2) and OR = 0.80 (95% CI 0.69, 0.93; P = 0.004), respectively (P(trend) = 0.02). There was no evidence of effect modification by tumor characteristics. rs10235235 was, however, associated with age at menarche in controls (P(trend) = 0.005) but not cases (P(trend) = 0.97). Consequently the association between rs10235235 and breast cancer risk differed according to age at menarche (P(het) = 0.02); the rare allele of rs10235235 was associated with a reduction in breast cancer risk for women who had their menarche age ≥15 years (OR(het) = 0.84, 95% CI 0.75, 0.94; OR(hom) = 0.81, 95% CI 0.51, 1.30; P(trend) = 0.002) but not for those who had their menarche age ≤11 years (OR(het) = 1.06, 95% CI 0.95, 1.19, OR(hom) = 1.07, 95% CI 0.67, 1.72; P(trend) = 0.29).

CONCLUSIONS:

To our knowledge rs10235235 is the first single nucleotide polymorphism to be associated with both breast cancer risk and age at menarche consistent with the well-documented association between later age at menarche and a reduction in breast cancer risk. These associations are likely mediated via an effect on circulating hormone levels.

PMID:
24887515
PMCID:
PMC4522594
DOI:
10.1186/bcr3662
[Indexed for MEDLINE]
Free PMC Article

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