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Retina. 2014 Sep;34(9):1757-66. doi: 10.1097/IAE.0000000000000174.

Supplementation with three different macular carotenoid formulations in patients with early age-related macular degeneration.

Author information

1
*Department of Optometry, School of Physics, Dublin Institute of Technology, Dublin, Ireland; †Macular Pigment Research Group, Waterford Institute of Technology, Waterford, Ireland; ‡Institute of Eye Surgery and Institute of Vision Research, Whitfield Clinic, Waterford, Ireland; §African Vision Research Institute, Faculty of Health Sciences, University of KwaZulu-Natal, Durban, South Africa; ¶Howard Foundation, Cambridge, United Kingdom; and **Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin.

Abstract

PURPOSE:

To investigate the impact of three different macular carotenoid formulations on macular pigment optical density and visual performance in subjects with early age-related macular degeneration.

METHODS:

Fifty-two subjects were supplemented and followed for 12 months, 17 of them were in intervention Group 1 (20 mg/day lutein and 2 mg/day zeaxanthin); 21 in Group 2 (10 mg/day meso-zeaxanthin, 10 mg/day lutein, and 2 mg/day zeaxanthin); and 14 in Group 3 (17 mg/day meso-zeaxanthin, 3 mg/day lutein, and 2 mg/day zeaxanthin). The macular pigment optical density was measured using customized heterochromatic flicker photometry, and visual function was assessed using corrected distance visual acuity and by letter contrast sensitivity.

RESULTS:

A statistically significant increase in the macular pigment optical density was observed at all measured eccentricities in Group 2 (P ≤ 0.005) and in Group 3 (P < 0.05, for all), but only at 1.75° in Group 1 (P = 0.018). Statistically significant (P < 0.05) improvements in letter contrast sensitivity were seen at all spatial frequencies (except 1.2 cycles per degree) in Group 3, and at low spatial frequencies in Groups 1 and 2.

CONCLUSION:

Augmentation of the macular pigment optical density across its spatial profile and enhancements in contrast sensitivity were best achieved after supplementation with a formulation containing high doses of meso-zeaxanthin in combination with lutein and zeaxanthin.

PMID:
24887490
DOI:
10.1097/IAE.0000000000000174
[Indexed for MEDLINE]

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