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Appl Radiat Isot. 2014 Sep;91:38-43. doi: 10.1016/j.apradiso.2014.05.006. Epub 2014 May 22.

Performance of a ⁶²Zn/⁶²Cu microgenerator in kit-based synthesis and delivery of [⁶²Cu]Cu-ETS for PET perfusion imaging.

Author information

1
Indiana University School of Medicine, Indianapolis, IN, USA.
2
Proportional Technologies, Inc. (PTI), Houston, TX, USA.
3
Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: magreen@iu.edu.

Abstract

The performance of a commercially produced (62)Zn/(62)Cu microgenerator system, and an associated kit-based radiopharmaceutical synthesis method, was evaluated for clinical site production of [(62)Cu]Cu-ETS (ethylglyoxal bis(thiosemicarbazonato)copper(II)), an investigational agent for PET perfusion imaging. Using 37 generators, containing 1.84±0.23 GBq (62)Zn at 9:00 AM on the day of clinical use, a total of 45 patient doses of [(62)Cu]Cu-ETS (672±172 MBq) were delivered without difficulty. (62)Cu elution yields were high (approximately 90%), accompanied by extremely low (62)Zn breakthrough (<0.001%). Radiopharmaceutical preparation, from the start-of-elution to time-of-injection, consumed less than five minutes. The (62)Zn/(62)Cu microgenerator was a dependable source of short-lived positron-emitting (62)Cu, and the kit-based synthesis proved to be rapid, robust, and highly reliable for "on-demand" delivery of [(62)Cu]Cu-ETS for PET perfusion imaging.

KEYWORDS:

(62)Zn/(62)Cu generator; PET radiopharmaceuticals; Tumor perfusion; [(62)Cu]Cu–ETS (copper(II) ethylglyoxal bis(thiosemicarbazone))

PMID:
24886964
PMCID:
PMC4209963
DOI:
10.1016/j.apradiso.2014.05.006
[Indexed for MEDLINE]
Free PMC Article

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