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J Pregnancy. 2014;2014:123024. doi: 10.1155/2014/123024. Epub 2014 May 5.

Revisiting the role of first trimester homocysteine as an index of maternal and fetal outcome.

Author information

1
Department of Reproductive Medicine, Christian Medical College, Vellore 632004, India.
2
Department of Obstetrics and Gynecology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry 605005, India.
3
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry 605005, India.

Abstract

AIM:

To revisit the role of first trimester homocysteine levels with the maternal and fetal outcome.

METHODS:

This was a cohort study comprising 100 antenatal women between 8 and 12 weeks of gestation. Serum homocysteine levels were checked after overnight fasting.

RESULTS:

There were significantly elevated homocysteine levels among women with prior history of hypertensive disorders of pregnancy and prior second or third trimester pregnancy losses. There was no significant difference in homocysteine levels among women with previous gestational diabetes mellitus, preterm deliveries, or fetal malformations. Homocysteine levels were significantly elevated in those who developed hypertensive disorder of pregnancy, oligohydramnios, and meconium stained amniotic fluid, had a pregnancy loss, or delivered a low birth weight baby. There was no significant difference in homocysteine levels for those who developed gestational diabetes mellitus.

CONCLUSIONS:

Increased first trimester serum homocysteine is associated with history of pregnancy losses, hypertensive disorders of pregnancy, and preterm birth. This is also associated with hypertensive disorders of pregnancy, pregnancy loss, oligohydramnios, meconium stained amniotic fluid, and low birth weight in the current pregnancy. This trial is registered with ClinicalTrials.gov CTRI/2013/02/003441.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT02003441.

PMID:
24883207
PMCID:
PMC4027023
DOI:
10.1155/2014/123024
[Indexed for MEDLINE]
Free PMC Article

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