Format

Send to

Choose Destination
J Physiol. 2014 Jun 1;592(11):2369-73. doi: 10.1113/jphysiol.2014.273045.

Non-coding RNAs as the bridge between epigenetic mechanisms, lineages and domains of life.

Author information

1
Department of Neurobiology, Wise Faculty of Life Sciences and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, 64332, Israel.
2
Department of Neurobiology, Wise Faculty of Life Sciences and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, 64332, Israel odedrechavi@gmail.com.

Abstract

Many cases of heritable environmental responses have been documented but the underlying mechanisms are largely unknown. Recently, inherited RNA interference has been shown to act as a multigenerational genome surveillance apparatus. We suggest that inheritance of regulatory RNAs is at the root of many other epigenetic phenomena, the trigger that induces other epigenetic mechanisms, such as the depositing of histone modifications and DNA methylation. In addition, we explore the possibility that interacting organisms influence each other's transcriptomes by exchanging heterologous non-coding RNAs.

PMID:
24882818
PMCID:
PMC4048094
DOI:
10.1113/jphysiol.2014.273045
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center