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Oncogene. 2015 Apr 9;34(15):1890-8. doi: 10.1038/onc.2014.127. Epub 2014 Jun 2.

RACK1, a versatile hub in cancer.

Author information

1
Center for Cancer Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China.

Abstract

RACK1 is a highly conserved intracellular adaptor protein with significant homology to Gβ and was originally identified as the anchoring protein for activated protein kinase C. In the past 20 years, the number of binding partners and validated cellular functions for RACK1 has increased, which facilitates clarification of its involvement in different biological events. In this review, we will focus on its role in cancer, summarizing its aberrant expression, pro- or anti-oncogenic effects and the underlying mechanisms in various cancers.

PMID:
24882575
DOI:
10.1038/onc.2014.127
[Indexed for MEDLINE]

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