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J Pediatr. 2014 Aug;165(2):372-375.e2. doi: 10.1016/j.jpeds.2014.04.033. Epub 2014 Jun 2.

Olfactory event-related potentials in infants.

Author information

1
Smell and Taste Clinic, Department of Otorhinolaryngology, Technical University of Dresden, Dresden, Germany.
2
Women's, Children's, and Adolecents' Department, Hospital Pedro Hispano, Matosinhos, Portugal.
3
Department of Otorhinolaryngology, Cliniques Universitaires Saint-Luc, Brussels, Belgium; Institute of Neuroscience, Université Catholique de Louvai, Brussels, Belgium.

Abstract

OBJECTIVES:

To evaluate olfactory event-related potentials (OERPs) as an objective measurement of olfactory function in infants.

STUDY DESIGN:

OERPs to phenylethyl alcohol were measured in 13 infants, between 23 and 41 days of age. The odor was delivered with a computer-controlled olfactometer. Recording electrodes were applied using the 10-20 system. Data from electrodes Fz, Cz, Pz, C3, and C4 were analyzed by MatLab's Letswave toolbox (André Mouraux, Brussels, Belgium) using the canonical time-domain averaging as well as the time-frequency analyzing method.

RESULTS:

Ten of 13 infants finished the recording session. We observed OERPs in 7 of these 10 infants. Recordings were best in electrodes Fz and Cz. The N1 peak was visible at 328 ms followed by P2 at 505 ms. In addition, the time-frequency analysis had an increase in low frequencies (4-7 Hz) around 550 ms after odor presentation.

CONCLUSIONS:

We were able to record OERPs in infants. The time-domain averaging as well as the time-frequency analysis was of value for data analysis.

PMID:
24882499
DOI:
10.1016/j.jpeds.2014.04.033
[Indexed for MEDLINE]

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