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FEBS Lett. 2014 Jun 27;588(14):2217-22. doi: 10.1016/j.febslet.2014.05.031. Epub 2014 May 29.

Synaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic β-cells.

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Université de Bordeaux, UMR CNRS 5248, F-33607 Pessac, France.
University of the Basque Country, Faculty of Medicine and Dentistry, Department of Physiology, Bilbao, Spain.
Université Montpellier 1, CNRS FRE 3400, Faculté de Pharmacie, F-34093 Montpellier Cedex 5, France.
Université de Bordeaux, UMR CNRS 5248, F-33607 Pessac, France. Electronic address:


Synaptotagmins are two C2 domain-containing transmembrane proteins. The function of calcium-sensitive members in the regulation of post-Golgi traffic has been well established whereas little is known about the calcium-insensitive isoforms constituting half of the protein family. Novel binding partners of synaptotagmin 11 were identified in β-cells. A number of them had been assigned previously to ER/Golgi derived-vesicles or linked to RNA synthesis, translation and processing. Whereas the C2A domain interacted with the Q-SNARE Vti1a, the C2B domain of syt11 interacted with the SND1, Ago2 and FMRP, components of the RNA-induced silencing complex (RISC). Binding to SND was direct via its N-terminal tandem repeats. Our data indicate that syt11 may provide a link between gene regulation by microRNAs and membrane traffic.


ER-Golgi; Pancreatic Islets; RISC; SNARE; Secretory pathway; Synaptotagmins

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