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Cell Metab. 2014 Jul 1;20(1):183-90. doi: 10.1016/j.cmet.2014.04.018. Epub 2014 May 29.

Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates.

Author information

1
Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, NIH, Suite 100, 251 Bayview Boulevard, Baltimore, MD 21224, USA.
2
Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Suite 100, 251 Bayview Boulevard, Baltimore, MD 21224, USA.
3
Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, NIH, Suite 100, 251 Bayview Boulevard, Baltimore, MD 21224, USA.
4
Program in Respiratory Biology and Lung Disease, Johns Hopkins Bloomberg School of Public Health, Room E7616, 615 North Wolfe Street, Baltimore, MD 21205, USA.
5
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Ross 1150, 720 Rutland Avenue, Baltimore, MD 21205, USA.
6
Laboratory of Clinical Investigation, Intramural Research Program, National Institute on Aging, NIH, Suite 100, 251 Bayview Boulevard, Baltimore, MD 21224, USA.
7
Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Suite 100, 251 Bayview Boulevard, Baltimore, MD 21224, USA; Mathematics and Statistics Department, Loyola University Maryland, Baltimore, MD 21210, USA.
8
Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Room 12-114, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
9
Systems Biology, Harvard Medical School, WA 536, Boston, MA 02115, USA.
10
Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma, BRC 1303, 975 Northeast 10th Street, Oklahoma City, OK 73104, USA.
11
National Institute of Allergy and Infectious Disease, NIH Animal Center, Building 102, 16701 Elmer School Road, Dickerson, MD 20842, USA.
12
Department of Pharmacology and Nutritional Sciences, University of Kentucky, C.T. Wethington Building, Room 591, 900 South Limestone, Lexington, KY 40536, USA.
13
Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, NIH, Suite 100, 251 Bayview Boulevard, Baltimore, MD 21224, USA. Electronic address: decabora@mail.nih.gov.

Abstract

Central arterial wall stiffening, driven by a chronic inflammatory milieu, accompanies arterial diseases, the leading cause of cardiovascular (CV) morbidity and mortality in Western society. An increase in central arterial wall stiffening, measured as an increase in aortic pulse wave velocity (PWV), is a major risk factor for clinical CV disease events. However, no specific therapies to reduce PWV are presently available. In rhesus monkeys, a 2 year diet high in fat and sucrose (HFS) increases not only body weight and cholesterol, but also induces prominent central arterial wall stiffening and increases PWV and inflammation. The observed loss of endothelial cell integrity, lipid and macrophage infiltration, and calcification of the arterial wall were driven by genomic and proteomic signatures of oxidative stress and inflammation. Resveratrol prevented the HFS-induced arterial wall inflammation and the accompanying increase in PWV. Dietary resveratrol may hold promise as a therapy to ameliorate increases in PWV.

PMID:
24882067
PMCID:
PMC4254394
DOI:
10.1016/j.cmet.2014.04.018
[Indexed for MEDLINE]
Free PMC Article
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