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Stem Cell Res. 2014 Nov;13(3 Pt B):571-81. doi: 10.1016/j.scr.2014.04.010. Epub 2014 May 6.

Harnessing Hippo in the heart: Hippo/Yap signaling and applications to heart regeneration and rejuvenation.

Author information

1
Department of Cardiology, Children's Hospital Boston, USA.
2
Department of Cardiology, Children's Hospital Boston, USA; Harvard Stem Cell Institute, Harvard University, USA. Electronic address: wpu@enders.tch.harvard.edu.

Abstract

The adult mammalian heart exhibits limited regenerative capacity after myocardial injury, a shortcoming that is responsible for the current lack of definitive treatments for heart failure. A search for approaches that might enhance adult heart regeneration has led to interest in the Hippo/Yap signaling pathway, a recently discovered signaling pathway that regulates cell proliferation and organ growth. Here we provide a brief overview of the Hippo/Yap pathway and its known roles in the developing and adult heart. We discuss the implications of Hippo/Yap signaling for regulation of cardiomyocyte death and regeneration.

PMID:
24881775
PMCID:
PMC4223001
DOI:
10.1016/j.scr.2014.04.010
[Indexed for MEDLINE]
Free PMC Article
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