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Nat Genet. 2014 Jul;46(7):678-84. doi: 10.1038/ng.2996. Epub 2014 Jun 1.

Identification of erythroferrone as an erythroid regulator of iron metabolism.

Author information

1
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
2
1] Department of Pediatrics, Division of Hematology-Oncology, Weill Cornell Medical College, New York, New York, USA. [2] Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, New York, USA.
3
1] Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA. [2] Department of Pathology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.

Abstract

Recovery from blood loss requires a greatly enhanced supply of iron to support expanded erythropoiesis. After hemorrhage, suppression of the iron-regulatory hormone hepcidin allows increased iron absorption and mobilization from stores. We identified a new hormone, erythroferrone (ERFE), that mediates hepcidin suppression during stress erythropoiesis. ERFE is produced by erythroblasts in response to erythropoietin. ERFE-deficient mice fail to suppress hepcidin rapidly after hemorrhage and exhibit a delay in recovery from blood loss. ERFE expression is greatly increased in Hbb(th3/+) mice with thalassemia intermedia, where it contributes to the suppression of hepcidin and the systemic iron overload characteristic of this disease.

PMID:
24880340
PMCID:
PMC4104984
DOI:
10.1038/ng.2996
[Indexed for MEDLINE]
Free PMC Article

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