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Drug Discov Today. 2014 Aug;19(8):1172-7. doi: 10.1016/j.drudis.2014.05.014. Epub 2014 May 28.

Cellular and molecular mechanisms of cartilage damage and repair.

Author information

1
Barts and The London, Queen Mary University of London School of Medicine and Dentistry, William Harvey Research Institute, London, UK.
2
Barts and The London, Queen Mary University of London School of Medicine and Dentistry, William Harvey Research Institute, London, UK. Electronic address: f.dellaccio@qmul.ac.uk.

Abstract

Cartilage breakdown is the disabling outcome of rheumatic diseases, whether prevalently inflammatory such as rheumatoid arthritis or prevalently mechanical such as osteoarthritis (OA). Despite the differences between immune-mediated arthritides and OA, common mechanisms drive cartilage breakdown. Inflammation, chondrocyte phenotype and homeostatic mechanisms have recently been the focus of research and will be summarised in this review.

PMID:
24880104
DOI:
10.1016/j.drudis.2014.05.014
[Indexed for MEDLINE]

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