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Prog Neuropsychopharmacol Biol Psychiatry. 2014 Oct 3;54:26-30. doi: 10.1016/j.pnpbp.2014.05.013. Epub 2014 May 29.

Roles of olfactory system dysfunction in depression.

Author information

1
School of Psychology, Nanjing Normal University, China. Electronic address: ytf0707@126.com.
2
Department of Psychology, American University, United States.

Abstract

The olfactory system is involved in sensory functions, emotional regulation and memory formation. Olfactory bulbectomy in rat has been employed as an animal model of depression for antidepressant discovery studies for many years. Olfaction is impaired in animals suffering from chronic stress, and patients with clinical depression were reported to have decreased olfactory function. It is believed that the neurobiological bases of depression might include dysfunction in the olfactory system. Further, brain stimulation, including nasal based drug delivery could provide novel therapies for management of depression.

KEYWORDS:

Antidepressant; Depression; Limbic system; Neurogenesis; Olfactory bulbectomy

PMID:
24879990
DOI:
10.1016/j.pnpbp.2014.05.013
[Indexed for MEDLINE]

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