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Br J Ophthalmol. 2014 Nov;98(11):1484-91. doi: 10.1136/bjophthalmol-2013-304786. Epub 2014 May 30.

First clinicial results on the feasibility, quality and reproducibility of aberrometry-based intraoperative refraction during cataract surgery.

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Department of Ophthalmology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany South West Peninsula Postgraduate Medical Education, School of Ophthalmology, Plymouth, UK.
Department of Ophthalmology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany Care Vision, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
Department of Ophthalmology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.



To provide the first clinical data in determining the feasibility, quality and precision of intraoperative wavefront aberrometry (IWA)-based refraction in patients with cataract.


IWA refraction was recorded at 7 defined measurement points during standardised cataract surgery in 74 eyes of 74 consecutive patients (mean age 69±11.3 years). Precision and measurement quality was evaluated by the 'limits of agreement' approach, regression analysis, correlation analysis, Analysis of variance (ANOVA) and ORs for predicting measurement failure. Wavefront map (WFM) quality was objectivised and compared with the Pentacam Nuclear Staging analysis.


Out of 814 IWA measurement attempts, 462 WFMs could be obtained. The most successful readings (n=63) were achieved in aphakia with viscoelastic. The highest (50.63%, SD 20.23) and lowest (29.19%, SD 13.94) quality of WFMs across all measurement points were found after clear corneal incision and in pseudophakia with viscoelastic, respectively. High consistency across repeated measures were found for mean spherical equivalent (SE) differences in aphakia with -0.01D and pseudophakia with -0.01D, but ranges were high (limits of agreement +0.69 D and -0.72 D; +1.53 D and -1.54 D, respectively). With increasing WFM quality, higher precision in measurements was observed.


This is the first report addressing quality and reproducibility of WA in a large sample. IWA refraction in aphakia, for instance, appears to be reliable once stable and pressurised anterior chamber conditions are achieved. More efforts are required to improve the precision and quality of measurements before IWA can be used to guide the surgical refractive plan in cataract surgery.


Clinical Trial; Diagnostic tests/Investigation; Optics and Refraction

[Indexed for MEDLINE]

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