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Clin Infect Dis. 2014 Sep 15;59(6):862-5. doi: 10.1093/cid/ciu409. Epub 2014 May 30.

Antigen-specific B-cell response to 13-valent pneumococcal conjugate vaccine in asplenic individuals with β-thalassemia previously immunized with 23-valent pneumococcal polysaccharide vaccine.

Author information

1
Infectious Diseases Unit, First Department of Paediatrics, Aghia Sofia Children's Hospital.
2
Department of Biological Chemistry, Medical School.
3
Thalassemia Unit, Aghia Sofia Children's Hospital, University of Athens, Greece.

Abstract

Current guidelines recommend a combined schedule of a 13-valent pneumococcal conjugate vaccine (PCV13) and PPSV23 (23-valent polysaccharide vaccine) for asplenic individuals. We show that PCV13 induces a T-dependent immune response in asplenic individuals with β-thalassemia, but previous PPSV23s affect the memory B-cell response in a dose- and time-dependent manner. Clinical Trials Registration. NCT01846923.

KEYWORDS:

immunological hyporesponsiveness; immunological memory; memory B cells; pneumococcal vaccine

PMID:
24879786
DOI:
10.1093/cid/ciu409
[Indexed for MEDLINE]

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