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Eur J Prev Cardiol. 2015 May;22(5):648-55. doi: 10.1177/2047487314536694. Epub 2014 May 30.

No effect of n-3 fatty acids supplementation on NT-proBNP after myocardial infarction: the Alpha Omega Trial.

Author information

1
Department of Internal Medicine and Nephrology, Jeroen Bosch Hospital, Den Bosch, the Netherlands ellen.hoogeveen@planet.nl.
2
Division of Human Nutrition, Wageningen University, Wageningen, the Netherlands.
3
Department of Clinical Chemistry, Jeroen Bosch Hospital, Den Bosch, the Netherlands.
4
Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands.

Abstract

BACKGROUND:

heart failure is a major risk factor for cardiovascular mortality, for which n-3 fatty acids may have beneficial effects. We examined the effect of marine eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and plant-derived alpha-linolenic acid (ALA) on N-Terminal-pro Brain Natriuretic Peptide (NT-proBNP), a biomarker of heart failure.

METHODS:

we randomly assigned 4837 post-myocardial infarction patients, aged 60-80 years (82% men), to margarines supplemented with a targeted additional intake of 400 mg/day EPA and DHA, 2 g/day ALA, EPA-DHA plus ALA, or placebo for 40 months. In a random selection of 639 patients, NT-proBNP was determined both at baseline and at the end of follow-up. NT-proBNP was loge-transformed and analysed by type of treatment using analysis of covariance adjusting for baseline NT-proNBP.

RESULTS:

patients consumed on average 19.8 g margarine/day, providing an additional amount of 238 mg/day EPA with 158 mg/day DHA, 1.98 g/day ALA, or both, in the active-treatment groups. In the placebo group, the geometric mean level NT-proBNP increased from 245 ng/l (95%-confidence interval [CI]: 207-290) to 294 ng/l (95%-CI: 244-352) after 40 months (p = 0.001). NT-proBNP levels were not affected by ALA (+8% versus placebo; 95%-CI: -8% to +25%; p = 0.34), EPA-DHA (+2% versus placebo; 95%-CI: -14% to +18%; p = 0.78), nor EPA-DHA plus ALA (+9% versus placebo; 95%-CI: -8% to +25%; p = 0.31) treatment.

CONCLUSIONS:

supplementation with modest amounts of EPA-DHA, with or without ALA, did not have a significant effect on NT-proBNP levels in patients with a history of myocardial infarction.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00127452.

KEYWORDS:

NT-proBNP; alpha-linolenic acid; docosahexaenoic acid; eicosapentaenoic acid; n-3 Polyunsaturated fatty acids; randomized double-blind placebo-controlled trial

PMID:
24879357
DOI:
10.1177/2047487314536694
[Indexed for MEDLINE]

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