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J Endocrinol Invest. 2014 Sep;37(9):783-8. doi: 10.1007/s40618-014-0096-3. Epub 2014 May 31.

Review of the protective effects of rutin on the metabolic function as an important dietary flavonoid.

Author information

1
Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.

Abstract

BACKGROUND:

In recent years, flavonoids have been revealed to be helpful in the treatment of many diseases. Rutin (3,3',4',5,7-pentahydroxyflavone-3-rhamnoglucoside) is an important flavonoid that is consumed in the daily diet. It is also known as vitamin P and quercetin-3-O-rutinoside. In addition, it is found in many food items, vegetables, and beverages. The cytoprotective effects of rutin, including gastroprotective, hepatoprotective, and anti-diabetic effects, have been shown in several studies. Furthermore, rutin has several pharmacological effects such as anti-inflammatory and anti-glycation activities.

AIM:

This work reviewed characteristic, pharmacokinetic, and metabolic effects of rutin in all experimental and human studies.

CONCLUSIONS:

Based on the above summarized effects of rutin, this flavonoid appears to be a potent component that could be considered in the treatment of several gastrointestinal diseases and diabetes.

PMID:
24879037
DOI:
10.1007/s40618-014-0096-3
[Indexed for MEDLINE]

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