Format

Send to

Choose Destination
See comment in PubMed Commons below
Pulm Pharmacol Ther. 2014 Aug;28(2):154-7. doi: 10.1016/j.pupt.2014.05.004. Epub 2014 May 28.

Stability of cough reflex sensitivity during viral upper respiratory tract infection (common cold).

Author information

1
Albert Einstein College of Medicine, Bronx, NY, USA; Montefiore Medical Center, Bronx, NY, USA. Electronic address: pdicpin@gmail.com.
2
Albert Einstein College of Medicine, Bronx, NY, USA; Jacobi Medical Center, Bronx, NY, USA.
3
Procter & Gamble, Healthcare Division, Cincinnati, OH, USA.

Abstract

Cough is among the symptoms most commonly associated with an acute, viral upper respiratory tract infection (URI), such as the common cold. Two previous studies incorporating capsaicin cough challenge methodology have demonstrated that cough reflex sensitivity is transiently enhanced during URI. These studies used single measurements of cough reflex sensitivity during the URI period. To our knowledge, no previous studies have included multiple measurements of cough reflex sensitivity to capsaicin during a URI to evaluate the stability of this measure during the acute viral illness. In the current methodological investigation, we performed capsaicin cough challenges in 42 subjects with URI who were otherwise healthy, adult, nonsmokers (25 female). Subjects were enrolled within 72 h of onset of illness and randomly assigned to 3 groups (n = 14 each) that underwent cough reflex sensitivity measurement (C2 and C5) at days 0 and 1 for group 1; days 2 and 3 for group 2; or days 4 and 5 for group 3. Each subject returned 4-8 weeks post-viral infection to establish a healthy baseline measurement (recovery). Our results support that cough reflex sensitivity to capsaicin, as measured by C5, is a sensitive measure that remains stable during 6 days of a URI. These results suggest that cough reflex sensitivity measures in the presence of a URI provide a sensitive and reproducible approach that could be used in future investigations seeking to test experimental antitussive therapies.

KEYWORDS:

Antitussive; Capsaicin; Common cold; Cough; Upper respiratory tract infection

PMID:
24878421
DOI:
10.1016/j.pupt.2014.05.004
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center