Format

Send to

Choose Destination
See comment in PubMed Commons below
Reprod Toxicol. 2014 Aug;47:21-6. doi: 10.1016/j.reprotox.2014.05.007. Epub 2014 May 27.

Evidence that birth weight is decreased by maternal lead levels below 5μg/dl in male newborns.

Author information

1
Department of Epidemiology and Environmental Health, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan; Department of Midwifery and Women's Health, Kobe University Graduate School of Health Sciences, 7-10-2, Tomogaoka, Kobe 654-0142, Japan.
2
Department of Epidemiology and Environmental Health, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. Electronic address: kyokoya@juntendo.ac.jp.
3
Department of Epidemiology and Environmental Health, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
4
Department of Epidemiology and Environmental Health, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan; National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585, Japan.
5
Department of Clinical Laboratory Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
6
Department of Obstetrics and Gynecology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.

Abstract

To assess the association between birth weight and maternal blood lead (BPb) levels, 386 pregnant women and their newborn offspring were surveyed. Mean±SD (range) maternal BPb concentrations were 0.98±0.55 (0.10-3.99), 0.92±0.63 [<0.09 (limit of quantification)-3.96], and 0.99±0.66 (<0.09-3.96)μg/dl at 12, 25 and 36 weeks' gestation, respectively. Mean±SD (range) gestational age at delivery was 38.9±1.3 (35-41) weeks. In male newborns, a significant correlation between birth weight and logBPb at 12 weeks' gestation was observed (Spearman's rank correlation coefficient=-0.145, p<0.05). Multiple regression analysis indicated that birth weight was significantly inversely associated with logBPb at 12 weeks' gestation, controlling for possible confounding variables. These results suggest that low-level exposure to lead in early gestation could be a risk factor for reduced birth weight in male offspring.

KEYWORDS:

Birth weight; Lead; Pregnancy outcome; Prenatal exposure; Sex differences

PMID:
24878230
DOI:
10.1016/j.reprotox.2014.05.007
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center