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J Control Release. 2014 Aug 10;187:118-32. doi: 10.1016/j.jconrel.2014.05.035. Epub 2014 May 27.

Prostate cancer relevant antigens and enzymes for targeted drug delivery.

Author information

1
Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City 64108, USA.
2
Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City 64108, USA. Electronic address: chengkun@umkc.edu.

Abstract

Chemotherapy is one of the most widely used approaches in combating advanced prostate cancer, but its therapeutic efficacy is usually insufficient due to poor specificity and associated toxicity. Lack of targeted delivery to prostate cancer cells is also the primary obstacles in achieving feasible therapeutic effect of other promising agents including peptide, protein, and nucleic acid. Consequently, there remains a critical need for strategies to increase the selectivity of anti-prostate cancer agents. This review will focus on various prostate cancer-relevant antigens and enzymes that could be exploited for prostate cancer targeted drug delivery. Among various targeting strategies, active targeting is the most advanced approach to specifically deliver drugs to their designated cancer cells. In this approach, drug carriers are modified with targeting ligands that can specifically bind to prostate cancer-specific antigens. Moreover, there are several specific enzymes in the tumor microenvironment of prostate cancer that can be exploited for stimulus-responsive drug delivery systems. These systems can specifically release the active drug in the tumor microenvironment of prostate cancer, leading to enhanced tumor penetration efficiency.

KEYWORDS:

HER2; PSA; PSCA; PSMA; Prostate cancer; Tumor microenvironment

PMID:
24878184
PMCID:
PMC4079732
DOI:
10.1016/j.jconrel.2014.05.035
[Indexed for MEDLINE]
Free PMC Article

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