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Nanomedicine (Lond). 2014 Sep;9(13):1913-22. doi: 10.2217/nnm.14.100. Epub 2014 May 30.

Gold nanoprisms for photothermal cell ablation in vivo.

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1
Istituto di Cibernetica 'E.Caianiello', Consiglio Nazionale delle Ricerche, Via Campi Flegrei, 34, 80078, Pozzuoli, Italy.

Abstract

AIM:

To develop new methodologies for selective cell ablation in a temporally and spatially precise fashion in model organisms.

MATERIALS & METHODS:

living polyps (Hydra vulgaris) treated with gold nanoprisms were near-infrared (NIR) irradiated and the photothermal effects evaluated at whole-animal, cellular and molecular levels.

RESULTS:

Nanoprisms showed good efficiency of internalization in living specimens, with no sign of toxicity; under NIR irradiation they induced cell death and the overexpression of the hsp70 gene.

CONCLUSION:

gold nanoprisms could be employed as efficient heat mediators in model organisms, and NIR-triggered cell ablation may represent a new advanced tool to study cell function. Solving bioethical and economical issues, invertebrates may provide alternative models bridging the gap between cell research and preclinical studies of photothermal therapy.

KEYWORDS:

Hydra vulgaris; gold nanoparticles; hyperthermia; model organism; near-infrared light; photothermal cell ablation

PMID:
24877877
DOI:
10.2217/nnm.14.100
[Indexed for MEDLINE]
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