Format

Send to

Choose Destination
Blood. 2014 Jul 24;124(4):479-82. doi: 10.1182/blood-2014-05-516252. Epub 2014 May 29.

Molecular liaisons between erythropoiesis and iron metabolism.

Author information

1
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.

Abstract

Although most circulating iron in blood plasma is destined for erythropoiesis, the mechanisms by which erythropoietic demand modulates the iron supply ("erythroid regulators") remain largely unknown. Iron absorption, plasma iron concentrations, and tissue iron distribution are tightly controlled by the liver-produced hormone hepcidin. During the last decade, much progress has been made in elucidating hepcidin regulation by iron and inflammation. This review discusses the less understood mechanisms and mediators of hepcidin suppression in physiologically and pathologically stimulated erythropoiesis.

PMID:
24876565
PMCID:
PMC4110655
DOI:
10.1182/blood-2014-05-516252
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center