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Invest Ophthalmol Vis Sci. 2014 May 29;55(5):3344-51. doi: 10.1167/iovs.14-14149.

Genome-wide association studies of refractive error and myopia, lessons learned, and implications for the future.

Author information

1
Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom Centre for Paediatric Epidemiology and Biostatistics, University College London Institute of Child Health, London, United Kingdom.
2
Johns Hopkins School of Public Health, Baltimore, Maryland, United States.
3
Centre for Paediatric Epidemiology and Biostatistics, University College London Institute of Child Health, London, United Kingdom.
4
Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.

Abstract

The investigation of the genetic basis of refractive error and myopia entered a new stage with the introduction of genome-wide association studies (GWAS). Multiple GWAS on many ethnic groups have been published over the years, providing new insight into the genetic architecture and pathophysiology of refractive error. This is a review of the GWAS published to date, the main lessons learned, and future possible directions of genetic studies of myopia and refractive error.

KEYWORDS:

GWAS; genetic architecture; refractive error

PMID:
24876304
PMCID:
PMC4039381
DOI:
10.1167/iovs.14-14149
[Indexed for MEDLINE]
Free PMC Article

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