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Biochim Biophys Acta. 2014 Oct;1843(10):2184-94. doi: 10.1016/j.bbamcr.2014.05.011. Epub 2014 May 27.

At the right distance: ER-mitochondria juxtaposition in cell life and death.

Author information

1
Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, Via Orus 2, 35129 Padua, Italy; Department of Biology, University of Padua, Via G. Colombo 3, 35121 Padua, Italy.
2
Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, Via Orus 2, 35129 Padua, Italy; Department of Biology, University of Padua, Via G. Colombo 3, 35121 Padua, Italy. Electronic address: luca.scorrano@unipd.it.

Abstract

The interface between mitochondria and the endoplasmic reticulum is emerging as a crucial hub for calcium signalling, apoptosis, autophagy and lipid biosynthesis, with far reaching implications in cell life and death and in the regulation of mitochondrial and endoplasmic reticulum function. Here we review our current knowledge on the structural and functional aspects of this interorganellar juxtaposition. This article is part of a Special Issue entitled: Calcium Signaling In Health and Disease. Guest Editors: Geert Bultynck, Jacques Haiech, Claus W. Heizmann, Joachim Krebs, and Marc Moreau.

KEYWORDS:

Apoptosis; Ca(2+) signalling; Endoplasmic reticulum; Mitochondria; Mitofusin; Tethering

PMID:
24875902
DOI:
10.1016/j.bbamcr.2014.05.011
[Indexed for MEDLINE]
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