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Nat Cell Biol. 2014 Jun;16(6):504-6. doi: 10.1038/ncb2978.

A centrosomal route for cancer genome instability.

Author information

1
Cell Division and Cancer Group, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, E-28029 Madrid, Spain.

Abstract

Despite the widespread occurrence of aneuploidy in cancer cells, the molecular causes for chromosomal instability are not well established. Cyclin B2 is now shown to control a pathway - involving the centrosomal kinases aurora A and Plk1 and the tumour suppressor p53 - the alteration of which causes defective centrosome separation, aneuploidy and tumour development.

PMID:
24875738
DOI:
10.1038/ncb2978
[Indexed for MEDLINE]

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