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Nat Cell Biol. 2014 Jun;16(6):495-501. doi: 10.1038/ncb2979.

Cargo recognition and trafficking in selective autophagy.

Author information

1
Institute of Biochemistry II, Goethe University, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany.
2
1] Institute of Biochemistry II, Goethe University, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany [2] Buchmann Institute for Molecular Life Sciences, Max-von-Laue-Stra├če 15, D-60438 Frankfurt am Main, Germany.

Abstract

Selective autophagy is a quality control pathway through which cellular components are sequestered into double-membrane vesicles and delivered to specific intracellular compartments. This process requires autophagy receptors that link cargo to growing autophagosomal membranes. Selective autophagy is also implicated in various membrane trafficking events. Here we discuss the current view on how cargo selection and transport are achieved during selective autophagy, and point out molecular mechanisms that are congruent between autophagy and vesicle trafficking pathways.

PMID:
24875736
DOI:
10.1038/ncb2979
[Indexed for MEDLINE]

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