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Clin Perinatol. 2014 Jun;41(2):331-45. doi: 10.1016/j.clp.2014.02.006.

Complications associated with parenteral nutrition in the neonate.

Author information

1
Division of Neonatology and Developmental Biology, Department of Pediatrics, Mattel Children's Hospital, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: KCalkins@mednet.ucla.edu.
2
Division of Gastroenterology, Department of Pediatrics, Mattel Children's Hospital, University of California, 10833 Le Conte Avenue, MDCC, Los Angeles, Los Angeles, CA 90095-1752, USA.
3
Division of Neonatology and Developmental Biology, Department of Pediatrics, Mattel Children's Hospital, University of California, Los Angeles, Los Angeles, CA, USA.

Abstract

Although parenteral nutrition (PN) is life-sustaining, it is associated with many complications including parenteral nutrition-associated liver disease (PNALD) and central line-associated bloodstream infections (CLASBIs), which carry a high morbidity and mortality and impose a burden on the health care system. Evidence has emerged that the dose and composition of intravenous lipid products may alter the incidence of PNALD. However, other patient and PN-related factors, such as prematurity, birth weight, and gastrointestinal anatomy and function, are important. To improve neonatal care, future research on optimizing the content of PN and decreasing the incidence IFALD and CLASBIs is required.

KEYWORDS:

Infections; Lipids; Neonates; Parenteral nutrition; Parenteral nutrition–associated liver disease

PMID:
24873836
PMCID:
PMC5384841
DOI:
10.1016/j.clp.2014.02.006
[Indexed for MEDLINE]
Free PMC Article

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