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Mediators Inflamm. 2014;2014:979132. doi: 10.1155/2014/979132. Epub 2014 Apr 27.

Effects of antisense oligonucleotides against C-reactive protein on the development of atherosclerosis in WHHL rabbits.

Author information

1
Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Chuo-City 409-3898, Japan ; Department of Histology and Embryology, Xi'an Medical University, Xi'an 710021, China.
2
Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Chuo-City 409-3898, Japan ; Department of Pathology, Shengjing Hospital of China Medical University, Shenyang 110003, China.
3
Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Chuo-City 409-3898, Japan.
4
Department of Pathology, Shengjing Hospital of China Medical University, Shenyang 110003, China.
5
Experimental Animal Center and Animal Models for Cardiovascular Diseases, Kobe University School of Medicine, Kobe 6500017, Japan.
6
Isis Pharmaceuticals Inc., Carlsbad, CA 92008, USA.
7
Research Institute of Atherosclerotic Disease and Laboratory Animal Center, Xi'an Jiaotong University School of Medicine, Xi'an 710061, China.
8
Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China.

Abstract

Increased plasma levels of C-reactive protein (CRP) are closely associated with cardiovascular diseases, but whether CRP is directly involved in the pathogenesis of atherosclerosis is still under debate. Many controversial and contradictory results using transgenic mice and rabbits have been published but it is also unclear whether CRP lowering can be used for the treatment of atherosclerosis. In the current study, we examined the effects of the rabbit CRP antisense oligonucleotides (ASO) on the development of atherosclerosis in WHHL rabbits. CRP ASO treatment led to a significant reduction of plasma CRP levels; however, both aortic and coronary atherosclerotic lesions were not significantly changed compared to those of control WHHL rabbits. These results suggest that inhibition of plasma CRP does not affect the development of atherosclerosis in WHHL rabbits.

PMID:
24872601
PMCID:
PMC4020194
DOI:
10.1155/2014/979132
[Indexed for MEDLINE]
Free PMC Article
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