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Dev Cell. 2014 May 27;29(4):406-20. doi: 10.1016/j.devcel.2014.03.020.

Membrane-bound methyltransferase complex VapA-VipC-VapB guides epigenetic control of fungal development.

Author information

1
Department of Molecular Microbiology and Genetics, Georg August University, Grisebachstrasse 8, Göttingen 37077, Germany.
2
Department of Plant Biochemistry, Georg August University, Justus-von-Liebig-Weg 11, Göttingen 37077, Germany.
3
Department of Pharmaceutical Engineering, Woosuk University, Wanju 565-701, Korea.
4
Department of Pharmaceutical Engineering, Woosuk University, Wanju 565-701, Korea; Department of Molecular Biology, Chonbuk National University, Jeonju 561-756, Korea.
5
Department of Bioinformatics, Georg August University, Goldschmidtstrasse 1, Göttingen 37077, Germany.
6
Department of Molecular Biology, Chonbuk National University, Jeonju 561-756, Korea.
7
Division of Life Sciences, Wonkwang University, Iksan 570-749, Korea.
8
Department of Molecular Microbiology and Genetics, Georg August University, Grisebachstrasse 8, Göttingen 37077, Germany. Electronic address: gbraus@gwdg.de.

Abstract

Epigenetic and transcriptional control of gene expression must be coordinated in response to external signals to promote alternative multicellular developmental programs. The membrane-associated trimeric complex VapA-VipC-VapB controls a signal transduction pathway for fungal differentiation. The VipC-VapB methyltransferases are tethered to the membrane by the FYVE-like zinc finger protein VapA, allowing the nuclear VelB-VeA-LaeA complex to activate transcription for sexual development. Once the release from VapA is triggered, VipC-VapB is transported into the nucleus. VipC-VapB physically interacts with VeA and reduces its nuclear import and protein stability, thereby reducing the nuclear VelB-VeA-LaeA complex. Nuclear VapB methyltransferase diminishes the establishment of facultative heterochromatin by decreasing histone 3 lysine 9 trimethylation (H3K9me3). This favors activation of the regulatory genes brlA and abaA, which promote the asexual program. The VapA-VipC-VapB methyltransferase pathway combines control of nuclear import and stability of transcription factors with histone modification to foster appropriate differentiation responses.

PMID:
24871947
DOI:
10.1016/j.devcel.2014.03.020
[Indexed for MEDLINE]
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