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Am J Perinatol. 2014 Nov;31(10):883-90. doi: 10.1055/s-0033-1363163. Epub 2014 May 28.

The role of the reduction of spiral artery remodeling and heme oxygenase 1 in mediating AT1-AA-induced hypertension and intrauterine growth restriction in pregnant rats.

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Department of Obstetrics and Gynaecology, Shengjing Hospital of China Medical University, Shenyang, China.
Department of Obstetrics and Gynaecology, Beijing Ditan Hospital Capital Medical University, Beijing, China.



Recently, emerging evidence has indicated that preeclamptic women who have angiotensin receptor agonistic autoantibodies (AT1-AA), these antibodies contribute to features of the disease.


The purpose of this study was to determine the role of spiral artery remodeling in mediating AT1-AA-induced hypertension and intrauterine growth restriction in pregnant rats. We hypothesized that AT1-AA-mediated heme oxygenase 1 (HO-1) reduction contributes to decreased spiral artery remodeling. Rat AT1-AA and an HO-1 inducer were administered to pregnant rats.


Mean arterial pressure (MAP) increased from 98 ± 4 mm Hg in normal pregnant rats to 113 ± 6 mm Hg in AT1-AA-infused rats (p < 0.05), which was significantly attenuated by the HO-1 inducer (103 ± 2 mm Hg). Fetal weight was also attenuated by HO-1 inducer, and kidney and liver development was adversely affected. Spiral artery remodeling was significantly reduced in AT1-AA-treated pregnant rats compared with that in normal pregnant rats, and this was significantly ameliorated by an HO-1 inducer.


Our findings demonstrate that AT1-AA-mediated HO-1 reduction contributes to reduced spiral artery remodeling, and is one mechanism whereby AT1-AA mediates hypertension and intrauterine growth retardation.

[Indexed for MEDLINE]

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