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Sci Rep. 2014 May 29;4:5103. doi: 10.1038/srep05103.

Exposure to 1800 MHz radiofrequency radiation impairs neurite outgrowth of embryonic neural stem cells.

Author information

  • 11] Department of Occupational Health, Faculty of Preventive Medicine, Third Military Medical University, No.30 Gaotanyan Street, Chongqing 400038, China [2] Key Laboratory of Electromagnetic Radiation Protection, Third Military Medical University, No.30 Gaotanyan Street, Chongqing 400038, China.
  • 2Department of Occupational Health, Faculty of Preventive Medicine, Third Military Medical University, No.30 Gaotanyan Street, Chongqing 400038, China.

Abstract

A radiofrequency electromagnetic field (RF-EMF) of 1800 MHz is widely used in mobile communications. However, the effects of RF-EMFs on cell biology are unclear. Embryonic neural stem cells (eNSCs) play a critical role in brain development. Thus, detecting the effects of RF-EMF on eNSCs is important for exploring the effects of RF-EMF on brain development. Here, we exposed eNSCs to 1800 MHz RF-EMF at specific absorption rate (SAR) values of 1, 2, and 4 W/kg for 1, 2, and 3 days. We found that 1800 MHz RF-EMF exposure did not influence eNSC apoptosis, proliferation, cell cycle or the mRNA expressions of related genes. RF-EMF exposure also did not alter the ratio of eNSC differentiated neurons and astrocytes. However, neurite outgrowth of eNSC differentiated neurons was inhibited after 4 W/kg RF-EMF exposure for 3 days. Additionally, the mRNA and protein expression of the proneural genes Ngn1 and NeuroD, which are crucial for neurite outgrowth, were decreased after RF-EMF exposure. The expression of their inhibitor Hes1 was upregulated by RF-EMF exposure. These results together suggested that 1800 MHz RF-EMF exposure impairs neurite outgrowth of eNSCs. More attention should be given to the potential adverse effects of RF-EMF exposure on brain development.

PMID:
24869783
PMCID:
PMC4037711
DOI:
10.1038/srep05103
[PubMed - indexed for MEDLINE]
Free PMC Article
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