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Front Med Biol Eng. 1989;1(4):271-85.

Progress and recent topics in blood flow measurements.

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Department of Medical Engineering and Systems Cardiology, Kawasaki Medical School, Kurashiki, Japan.


Progress in both basic and clinical studies on the cardiovascular system has been tightly coupled to the innovation of methodology. The developments of blood flow measurements have greatly contributed to the understanding of blood supply to each organ and of hemodynamics. Recent advances in blood flow measurements involve (1) improvement of spatial and temporal resolution, (2) progress of accessibility of velocimeter, (3) introduction of non-invasive techniques, (4) new blood flow imaging techniques, (5) fabrication of a miniature Doppler catheter, etc. In this paper the characteristics of representative methods are summarized after a brief review of a historical perspective of blood flow measurements. Then, some results of our study on a laser Doppler velocimetry with an optical fiber and on a high frequency multichannel ultrasound Doppler method are described with special reference to their applications to the analysis of the coronary circulation. Finally, the present status of myocardial blood flow imaging techniques, e.g. radionuclide techniques, NMR-imaging and ultrafast CT, is briefly reviewed.

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