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Korean J Urol. 2014 May;55(5):349-53. doi: 10.4111/kju.2014.55.5.349. Epub 2014 May 12.

Unexpected Multidrug Resistance of Methicillin-Resistant Staphylococcus aureus in Urine Samples: A Single-Center Study.

Author information

1
Department of Urology, Hanusch Krankenhaus, Vienna, Austria.
2
Department of Pathology, Hanusch Krankenhaus, Vienna, Austria.
3
Department of Urology, Medical University Innsbruck, Innsbruck, Austria.

Abstract

PURPOSE:

Infections of methicillin-resistant Staphylococcus aureus (MRSA) are becoming an increasingly concerning clinical problem. The aim of this study was to assess the development of MRSA in urine cultures in a major public university-affiliated hospital and the therapeutical and hygiene-related possibilities for reducing resistance.

MATERIALS AND METHODS:

This study included 243 samples from patients diagnosed with MRSA infection over a period of 6 years. An agar diffusion test measured the effects of antimicrobial agents against bacteria grown in culture. The analyses were based on the guidelines of the Clinical and Laboratory Standards Institute.

RESULTS:

A regression analysis was performed, which showed 100% resistance to the following antibiotics throughout the entire testing period: carbapenem, cephalosporin (1st-4th generation), penicillin G, aminopenicillin, β-lactamase, and isoxazolyl penicillin. However, a significant decrease in resistance was found for amikacin, gentamicin, clindamycin, levofloxacin, erythromycin, and mupirocin.

CONCLUSIONS:

MRSA showed a decreasing trend of antimicrobial resistance, except against carbapenem, cephalosporin (1st-4th generation), penicillin G, aminopenicillin, β-lactamase, and isoxazolyl penicillin, for which complete resistance was observed.

KEYWORDS:

Methicillin-resistant Staphylococcus aureus; Multidrug resistance; Urine

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