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Prz Gastroenterol. 2013;8(6):350-3. doi: 10.5114/pg.2013.39917. Epub 2013 Dec 30.

Butyric acid in irritable bowel syndrome.

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Department of Paediatric Gastroenterology and Nutrition, Medical University of Warsaw, Poland.
Department of Paediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poland.


Butyric acid (butanoic acid) belongs to a group of short-chain fatty acids and is thought to play several beneficial roles in the gastrointestinal tract. Butyric anion is easily absorbed by enteric cells and used as a main source of energy. Moreover, butyric acid is an important regulator of colonocyte proliferation and apoptosis, gastrointestinal tract motility and bacterial microflora composition in addition to its involvement in many other processes including immunoregulation and anti-inflammatory activity. The pathogenesis of irritable bowel syndrome (IBS), the most commonly diagnosed functional gastrointestinal condition, is complex, and its precise mechanisms are still unclear. This article describes the potential benefits of butyric acid in IBS.


butyric acid; irritable bowel syndrome; sodium butyrate

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