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Blood. 2014 Jul 10;124(2):184-7. doi: 10.1182/blood-2014-03-562538. Epub 2014 May 27.

Paraneoplastic thrombocytosis: the secrets of tumor self-promotion.

Author information

1
Department of Medicine, Weill Cornell Medical College, New York, NY; and.
2
Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.

Abstract

Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with reciprocal interactions between tumor growth/metastasis and thrombocytosis/platelet activation. Specific molecular pathways have been identified in which tumors can stimulate platelet production and activation; activated platelets can, in turn, promote tumor growth and metastasis. Taken together, these findings provide exciting new potential targets for therapeutic intervention.

PMID:
24868077
PMCID:
PMC4093679
DOI:
10.1182/blood-2014-03-562538
[Indexed for MEDLINE]
Free PMC Article

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