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Antimicrob Agents Chemother. 2014 Aug;58(8):4931-4. doi: 10.1128/AAC.02590-14. Epub 2014 May 27.

Bordetella pertussis lipid A glucosamine modification confers resistance to cationic antimicrobial peptides and increases resistance to outer membrane perturbation.

Author information

1
Department of Microbiology and Immunology, The University of British Columbia, Vancouver, Canada.
2
Department of Microbiology and Immunology, The University of British Columbia, Vancouver, Canada rachelf@mail.ubc.ca.

Abstract

Bordetella pertussis, the causative agent of whooping cough, has many strategies for evading the human immune system. Lipopolysaccharide (LPS) is an important Gram-negative bacterial surface structure that activates the immune system via Toll-like receptor 4 and enables susceptibility to cationic antimicrobial peptides (CAMPs). We show modification of the lipid A region of LPS with glucosamine increased resistance to numerous CAMPs, including LL-37. Furthermore, we demonstrate that this glucosamine modification increased resistance to outer membrane perturbation.

PMID:
24867963
PMCID:
PMC4136009
DOI:
10.1128/AAC.02590-14
[Indexed for MEDLINE]
Free PMC Article

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