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Neurol Sci. 2014 May;35 Suppl 1:141-4. doi: 10.1007/s10072-014-1755-z.

Riboflavin and migraine: the bridge over troubled mitochondria.

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Headache Unit, Department of Neurology, San Raffaele Hospital, University Vita-Salute, Via Olgettina 48, 20132, Milan, Italy,


Brain energy metabolism has been found to be disturbed in migraine. A mitochondrial defect may reduce the threshold for migraine attacks both increasing neuronal excitability and leading migrainous brain to a hyper-responsiveness to triggering stimuli. Riboflavin, a major co-factor in oxidative metabolism, may overcome this impairment. RCT studies in adult confirmed that riboflavin is safe and probably effective in migraine prophylaxis, based on level B evidence. Improving brain energy metabolism may reduce the susceptibility to migraine when brain energy demand increases due to both physiological and biopsychological factors.

[Indexed for MEDLINE]

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