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Clin Infect Dis. 2014 Sep 1;59(5):682-5. doi: 10.1093/cid/ciu384. Epub 2014 May 27.

Etiology of severe childhood pneumonia in the Gambia, West Africa, determined by conventional and molecular microbiological analyses of lung and pleural aspirate samples.

Author information

1
Medical Research Council Unit, Fajara, Republic of The Gambia.
2
Center for Infection and Immunity, Columbia University, New York, New York.
3
Ministry of Health and Social Welfare, Banjul, Republic of The Gambia.
4
Centre for International Health, University of Otago, Dunedin, New Zealand.
5
London School of Hygiene and Tropical Medicine, United Kingdom.
6
Medical Research Council Unit, Fajara, Republic of The Gambia GlaxoSmithKline Vaccines, Wavre, Belgium.

Abstract

Molecular analyses of lung aspirates from Gambian children with severe pneumonia detected pathogens more frequently than did culture and showed a predominance of bacteria, principally Streptococcus pneumoniae, >75% being of serotypes covered by current pneumococcal conjugate vaccines. Multiple pathogens were detected frequently, notably Haemophilus influenzae (mostly nontypeable) together with S. pneumoniae.

KEYWORDS:

Gambia; children; etiology; lung aspirate; pneumonia

PMID:
24867789
PMCID:
PMC4130311
DOI:
10.1093/cid/ciu384
[Indexed for MEDLINE]
Free PMC Article

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