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Infect Immun. 2014 Aug;82(8):3090-7. doi: 10.1128/IAI.01722-14. Epub 2014 May 27.

Complex immune cell interplay in the gamma interferon response during Toxoplasma gondii infection.

Author information

1
Department of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
2
Department of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas, USA felix.yarovinsky@utsouthwestern.edu.

Abstract

Toxoplasma gondii is an obligate intracellular parasite of clinical importance, especially in immunocompromised patients. Investigations into the immune response to the parasite found that T cells are the primary effector cells regulating gamma interferon (IFN-γ)-mediated host resistance. However, recent studies have revealed a critical role for the innate immune system in mediating host defense independently of the T cell responses to the parasite. This body of knowledge is put into perspective by the unifying theme that immunity to the protozoan parasite requires a strong IFN-γ host response. In the following review, we discuss the role of IFN-γ-producing cells and the signals that regulate IFN-γ production during T. gondii infection.

PMID:
24866795
PMCID:
PMC4136216
DOI:
10.1128/IAI.01722-14
[Indexed for MEDLINE]
Free PMC Article

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